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This combination should be avoided.Fluconazole should be administered with caution to patients with renal dysfunction.Adrenal insufficiency has been reported in patients receiving azoles, including fluconazole.

Because fluconazole was given as a single dose, no discontinuations occurred.An open-label, comparative study of the efficacy and safety of DIFLUCAN (2 to 3 mg/kg/day) and oral nystatin (400,000 I.U. In post-marketing experience, spontaneous reports of anemia and acute renal failure were more frequent among patients 65 years of age or older than in those between 12 and 65 years of age. There was a significant increase in phenytoin AUC.

Fluconazole is designated chemically as 2,4-difluoro-α,αFluconazole is a white crystalline solid which is slightly soluble in water and saline.DIFLUCAN Tablets contain 50 mg, 100 mg, 150 mg, or 200 mg of fluconazole and the following inactive ingredients: microcrystalline cellulose, dibasic calcium phosphate anhydrous, povidone, croscarmellose sodium, FD&C Red No.

These effects are consistent with the inhibition of estrogen synthesis in rats and may be a result of known effects of lowered estrogen on pregnancy, organogenesis, and parturition.Fluconazole was present in low levels in breast milk following administration of a single 150 mg dose, based on data from a study in 10 breastfeeding women who temporarily or permanently discontinued breastfeeding 5 days to 19 months postpartum.

Fluconazole can increase halofantrine plasma concentration due to an inhibitory effect on CYP3A4.The risk of myopathy and rhabdomyolysis increases when fluconazole is coadministered with HMG-CoA reductase inhibitors metabolized through CYP3A4, such as atorvastatin and simvastatin, or through CYP2C9, such as fluvastatin.

Also tested negative for diabets. The dose of DIFLUCAN may need to be reduced in patients with impaired renal function. Patients with AIDS and cryptococcal meningitis or recurrent oropharyngeal candidiasis usually require maintenance therapy to prevent relapse.The recommended dosage of DIFLUCAN for oropharyngeal candidiasis is 200 mg on the first day, followed by 100 mg once daily. There have been reports of uveitis in patients to whom fluconazole and rifabutin were coadministered. A few published case reports describe a pattern of distinct congenital anomalies in infants exposed Case reports describe a distinctive and rare pattern of birth defects among infants whose mothers received high-dose (400 to 800 mg/day) fluconazole during most or all of the first trimester of pregnancy. Dosage of orally administered tacrolimus should be decreased depending on tacrolimus concentration. Patients with esophageal candidiasis should be treated for a minimum of three weeks and for at least 2 weeks following the resolution of symptoms.For the treatment of acute cryptococcal meningitis, the recommended dosage is 12 mg/kg on the first day, followed by 6 mg/kg once daily. Signs of an allergic reaction can include shortness of breath; coughing; wheezing; fever; chills; throbbing of the heart or ears; swelling of the eyelids, face, mouth, neck, or any other part of the body; or skin rash, hives, blisters or skin peeling.Tell your doctor or pharmacist if you experience skin rash, fever, swollen glands, increase in a type of white blood cell (eosinophilia), and inflammation of internal organs (liver, lungs, heart, kidneys, and large intestine) as they may be signs of a hypersensitivity reaction (Drug Reaction or rash with Eosinophilia and Systemic Symptoms (DRESS)).DIFLUCAN has been linked to rare cases of serious liver damage, including deaths, mostly in patients with serious medical problems.

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An oral dose of 7.5 mg of midazolam was ingested after fluconazole/placebo. Careful monitoring of phenytoin concentrations in patients receiving DIFLUCAN and phenytoin is recommended. Fluconazole treatment did not cause a decrease in the ethinyl estradiol AUC of any individual subject in this study compared to placebo dosing. )DIFLUCAN is administered orally. The majority of treatment-related laboratory abnormalities were elevations of transaminases or alkaline phosphatase.There have been reports of overdose with fluconazole accompanied by hallucination and paranoid behavior.In the event of overdose, symptomatic treatment (with supportive measures and gastric lavage if clinically indicated) should be instituted.Fluconazole is largely excreted in urine. Dosage adjustment of methadone may be necessary.

The order of study treatment was random.

Another study at a 400 mg and 800 mg daily dose of fluconazole demonstrated that DIFLUCAN taken in doses of 400 mg/day or greater significantly increases plasma levels of terfenadine when taken concomitantly.

(See The use of DIFLUCAN in children with cryptococcal meningitis, In a noncomparative study of children with serious systemic fungal infections, most of which were candidemia, the effectiveness of DIFLUCAN was similar to that reported for the treatment of candidemia in adults. range: 18 to 31%) and 13% (95% C.I. There were significant increases in theophylline AUC, CSix healthy volunteers received terfenadine 60 mg BID for 15 days. One study at a 200 mg daily dose of fluconazole failed to demonstrate a prolongation in QTc interval.

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