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Response to vitamin D can be monitored through serum calcium levels, which should be maintained at 9—10 mg/dL.

Calcitriol should not be used with other vitamin D products because of the increased risk of additive side effects and toxicity. Cholestyramine (), colestipol (), mineral oil, and orlistat (Alli, Xenical) may decrease the intestinal absorption of calcitriol.Separating the administration of these medications and calcitriol may prevent this interaction. Management: Avoid coadministration of serum phosphate level-altering agents with erdafitinib before initial dose increase period based on serum phosphate levels (Days 14 to 21).Mineral Oil: May decrease the serum concentration of Vitamin D Analogs.

Thiazide and Thiazide-Like Diuretics: May enhance the hypercalcemic effect of Vitamin D Analogs.Vitamin D Analogs: May enhance the adverse/toxic effect of other Vitamin D Analogs.The activation of the vitamin D receptor is part of the vitamin D endocrine system and it is described by the production of a change in the transcription rates of the vitamin D receptor target genes.The target genes in the DNA affected by the presence of ergocalciferol are called vitamin D response elements which are dependent on co-modulators.The vitamin D receptor is a transcription factor and member of the steroid hormone nuclear receptor family. Monitor plasma calcium concentrations.Calcium Salts: May enhance the adverse/toxic effect of Vitamin D Analogs.Cardiac Glycosides: Vitamin D Analogs may enhance the arrhythmogenic effect of Cardiac Glycosides. Specifically, the absorption of aluminum from sucralfate may be increased, leading to an increase in the serum aluminum concentration. Vitamin D metabolites also mobilize calcium and phosphate from bone and probably increase the reabsorption of calcium and perhaps also of phosphate by the renal 4 tubules. Vitamin D metabolites promote the active absorption of calcium and phosphorus by the small intestine, thus elevating serum calcium and phosphate levels sufficiently to permit bone mineralization. Parathyroid hormone is responsible for the regulation of this metabolism in the kidneys. Separate administration of these agents by several hours to minimize the potential risk of interaction. Your doctor may check your Tell your doctor right away if any of these unlikely but serious side effects occur: loss of appetite, back/bone/This is not a complete list of possible side effects. Your doctor may start you on a low dose and adjust the dose slowly to find the best dose for you. Calcitriol, the active form of vitamin D (1,25 hydroxyvitamin D 3), binds to and activates the vitamin D receptor in kidney, parathyroid gland, intestine, and bone, stimulating intestinal calcium transport and absorption.It reduces parathyroid hormone (PTH) levels and improves calcium and phosphate homeostasis by stimulating bone resorption of calcium and increasing renal tubular … In patients in whom serum parathyroid hormone levels are progressively rising and remain persistently elevated despite correction of modifiable factors (eg, hyperphosphatemia, vitamin D deficiency), calcitriol or vitamin D analogs are suggested instead of ergocalciferol (or cholecalciferol).Bile Acid Sequestrants: May decrease the serum concentration of Vitamin D Analogs. It is characterized to present weak or soft bones.

Hypoparathyroidism is the result of inadequate parathyroid hormone production that occurs due to the presence of damage or removal of the parathyroid glands. Do not double the dose to catch up.Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Monitor plasma calcium concentrations.Multivitamins/Fluoride (with ADE): May enhance the adverse/toxic effect of Vitamin D Analogs.Multivitamins/Minerals (with ADEK, Folate, Iron): May enhance the adverse/toxic effect of Vitamin D Analogs.Orlistat: May decrease the serum concentration of Vitamin D Analogs. If you notice other effects not listed above, contact your doctor or Call your doctor for medical advice about side effects. Vitamin D helps control parathyroid hormone and the levels of certain ... mineral oil, orlistat) can decrease the absorption of vitamin D ... Calcitriol is very similar to other forms of vitamin D Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Nutrients. Like calcidiol and 25-hydroxylase, low concentrations of calcitriol stimulate 1-alpha-hydroxylase activity, which also is influenced by parathyroid hormone (PTH) and serum calcium concentrations; high levels of PTH and calcium inhibit the enzyme, while low levels stimulate it.

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