lorcaserin mechanism of action finpecia

27 Lorcaserin reduces food intake, possibly via suppressing appetite and increasing satiety, but the exact mechanism of action is unknown. 0000395835 00000 n 0000433025 00000 n 0000367544 00000 n 0000371199 00000 n 0000366918 00000 n The drug has a high affinity for the human 5-HT 2C. 0000035053 00000 n 0000004103 00000 n The restrictions include patients with a The safety and efficacy of Belviq were evaluated in three randomized, placebo-controlled trials that included nearly 8,000 obese and overweight patients, with and without type 2 diabetes, treated for 52 to 104 weeks.About 47 percent of patients without type 2 diabetes lost at least 5 percent of their body weight compared with about 23 percent of patients treated with placebo.The drug's manufacturer was required to conduct six postmarketing studies, including a long-term cardiovascular outcomes trial to assess the effect of Belviq on the risk for major adverse cardiac events such as heart attack and stroke.On July 15, 2016, the extended release version of lorcaserin was approved for use in the United States.InChI=1S/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1 0000003968 00000 n trailer

Lorcaserin Mechanism of Action. 0000413752 00000 n It is assumed that Lorcaserin activates serotonin receptors in hypothalamus, thereby: Suppressing the appetite and increasing the satiety

management in clinically obese adults (BMI of 30 kg/m2 or greater) and overweight adults (BMI of 27 kg/m2 or greater) with at least one weight-related comorbid condition. Lorcaserin belongs to a class of drugs known as serotonin receptor agonists.

It has been shown to decrease food consumption and promote satiety by selectively activating serotonin 2C receptors in the brain.Belviq is specifically indicated as an adjunct to a 0000051850 00000 n

MECHANISM OF ACTION. The exact mechanism of action is not known, but lorcaserin is believed to promote satiety and decrease food intake by activating 5-HT(2C) receptors on anorexigenic pro-opiomelanocortin neurons in the hypothalamus.

Belviq (lorcaserin hydrochloride) is a serotonin 2C receptor agonist. 0000554352 00000 n 0000514732 00000 n

0000002484 00000 n By representing the data as an activity curve, it is clearly seen that lorcaserin has no activity on PRE084 in the BiP – Sig-1R association SUMMARY OF RESULTS 0000553976 00000 n

0000035601 00000 n < 0000553937 00000 n xref See full prescribing information for BELVIQ. 0000451225 00000 n Lorcaserin at the recommended daily dose selectively interacts with 5-HT2C receptors as compared to 5-HT2A and 5-HT2B receptors (see Table 5), other 5-HT receptor subtypes, the 5 … 0000555060 00000 n Lorcaserin N-carbamoyl glucuronidation governs the predominant excretory pathway of lorcaserin in humans. 0000367316 00000 n Linezolid: (Major) Based on the mechanism of action of lorcaserin and the theoretical potential for serotonin syndrome, use with extreme caution in combination with other drugs that may affect the serotonergic neurotransmitter systems, including linezolid, an antibiotic that is also a reversible, non-selective MAO inhibitor.

0000490818 00000 n The restrictions include patients with a The safety and efficacy of Belviq were evaluated in three randomized, placebo-controlled trials that included nearly 8,000 obese and overweight patients, with and without type 2 diabetes, treated for 52 to 104 weeks.About 47 percent of patients without type 2 diabetes lost at least 5 percent of their body weight compared with about 23 percent of patients treated with placebo.The drug's manufacturer was required to conduct six postmarketing studies, including a long-term cardiovascular outcomes trial to assess the effect of Belviq on the risk for major adverse cardiac events such as heart attack and stroke.On July 15, 2016, the extended release version of lorcaserin was approved for use in the United States.InChI=1S/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1 Lorcaserin, a selective serotonin 5-HT(2C) receptor agonist, is a weight management agent in clinical development. 0000016798 00000 n 0000399617 00000 n

0000005431 00000 n BELVIQ is a serotonin 2C receptor agonist indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight 0000451502 00000 n The exact mechanism of action is not known.

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