meropenem indications elocon

Excipients with known effect: Each vial contains 208 mg sodium carbonate approximately 4.0 mmol of sodium (approximately 90 mg).. Each ml of reconstituted solution contains 50 mg Meropenem. Meropenem is a broad-spectrum antibacterial agent of the carbapenem family. Some corticosteroids have been shown to be teratogenic after dermal application in laboratory animals.When administered to pregnant rats, rabbits, and mice, mometasone furoate increased fetal malformations. May also contain phosphoric acid used to adjust the pH to approximately 4.5.Like other topical corticosteroids, mometasone furoate has anti-inflammatory, antipruritic, and vasoconstrictive properties. Studies in humans indicate that approximately 0.7% of the applied dose of ELOCON Ointment enters the circulation after 8 hours of contact on normal skin without occlusion. Meropenem is a carbapenem antibiotic that appears to be widely distributed in tissues and is eliminated by both excretion and metabolism. Mometasone furoate is a synthetic corticosteroid with anti-inflammatory activity. In a 2-year carcinogenicity study in Sprague Dawley rats, mometasone furoate demonstrated no statistically significant increase of tumors at inhalation doses up to 67 mcg/kg (approximately 0.04 times the estimated maximum clinical topical dose from Elocon Lotion on a mcg/mMometasone furoate increased chromosomal aberrations in an In reproductive studies in rats, impairment of fertility was not produced in male or female rats by subcutaneous doses up to 15 mcg/kg (approximately 0.01 times the estimated maximum clinical topical dose from Elocon Lotion on a mcg/mThe safety and efficacy of Elocon Lotion, 0.1% for the treatment of corticosteroid-responsive dermatoses was demonstrated in two vehicle-controlled trials, one in scalp psoriasis and one in seborrheic dermatitis. Reported reactions included acneiform reaction, 2; burning, 4; and itching, 1. If a favorable response does not occur promptly, use of Elocon Lotion should be discontinued until the infection has been adequately controlled.Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.In clinical trials involving 209 subjects, the incidence of adverse reactions associated with the use of Elocon Lotion was 3%. In approximately 29% of subjects who showed normal adrenal function by Cortrosyn test before starting treatment, adrenal suppression was observed at the end of treatment with Elocon Lotion. considered susceptible to meropenem for approved indications, and meropenem need not be tested. Important information: Elocon Lotion is for use on skin only.Before using Elocon Lotion, tell your healthcare provider about all your medical conditions, including if you:Tell your healthcare provider about all the medicines you take,What are the possible side effects of Elocon Lotion?Elocon Lotion may cause serious side effects, including:The most common side effects of Elocon Lotion includeKeep Elocon Lotion and all medicines out of the reach of children.General information about the safe and effective use of Elocon Lotion.We comply with the HONcode standard for trustworthy health information - Mechanism of action of meropenem. (Doses of 20, 60, and 180 mcg/kg in the mouse are approximately 0.01, 0.02, and 0.05 times the estimated maximum clinical topical dose from Elocon Lotion on a mcg/mIn rats, mometasone furoate produced umbilical hernias at topical doses of 600 mcg/kg and above. Elocon Lotion was applied once daily for approximately 3 weeks over a mean body surface area of 40% (range 16%-90%). Therefore, Elocon Lotion should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.Corticosteroids have been shown to be teratogenic in laboratory animals when administered systemically at relatively low dosage levels. Pediatric patients applying topical corticosteroids to greater than 20% of body surface are at higher risk of HPA axis suppression.HPA axis suppression, Cushing's syndrome, linear growth retardation, delayed weight gain, and intracranial hypertension have been reported in pediatric patients receiving topical corticosteroids. Avoid contact with eyes. Cataracts and glaucoma have been reported in postmarketing experience with the use of topical corticosteroid products, including the topical mometasone products Avoid contact of Elocon Lotion with eyes. Mometasone furoate also caused dystocia and related complications when administered to rats during the end of pregnancy.In mice, mometasone furoate caused cleft palate at subcutaneous doses of 60 mcg/kg and above. The doses that produced malformations also decreased fetal growth, as measured by lower fetal weights and/or delayed ossification. Fetal survival was reduced at 180 mcg/kg. As the product dissolves carbon dioxide is released creating a positive pressure in the vial. At the end of treatment, the plasma cortisol levels for each of the 4 subjects remained within the normal range and changed little from baseline.If HPA axis suppression is documented, an attempt should be made to gradually withdraw the drug, to reduce the frequency of application, or to substitute a less potent corticosteroid. The criteria for suppression were: basal cortisol level of ≤5 mcg/dL, 30-minute post-stimulation level of ≤18 mcg/dL, or an increase of <7 mcg/dL.

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