methotrexate and dexamethasone

Free PMC article Given the small number of patients, these factors cannot be statistically discarded as a Type II error. Cancer Chemother Pharmacol 2013;72:201-7.16. Atypon Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China.Correspondence Address: Dr. Hui Bu, Department of Neurology, The Second Hospital of Hebei Medical University, 215 West Road of Peace, Shijiazhuang 050000, Hebei, China. Minchom A, Chan S, Melia W, Shah R. An unusual case of pancreatic cancer with leptomeningeal infiltration. Vojnosanit Pregl 2012;69:209-13.17. Then the patients underwent treatments with a dehydrating agent, pain killer drugs, benzodiazepines, as well as other supportive treatments in the hospital. The 5-year OS rates for C-MTX and HD-MTX were 90.7 ± 1.3% and 91.8 ± 1.2%, respectively. Copyright © 2020 OAE Publishing Inc. All Rights Reserved. Int J Clin Oncol 2012;17:361-6.18. Dexamethasone given during induction benefited younger children but provided no benefit and was associated with a … The medium survival accords with William R and Theodore’s report,Among all those factors, IT DXM and MTX prolong the survival, while spinal nerves damage shortens the OS. Local therapy consisted of a cycle to each eye of 3 intravitreal injections of methotr … During the injection, dexamethasone sodium phosphate was mixed with drawing back CSF repeatedly. Le Rhun E, Taillibert S, Chamberlain MC. Methotrexate was diluted to 5 mL and then injected the same way dexamethasone was treated. Clin Exp Metastasis 2010;27:19-23.3. Please enable it to take advantage of the complete set of features! Oechsle K, Lange-Brock V, Kruell A, Bokemeyer C, de Wit M. Prognostic factors and treatment options in patients with leptomeningeal metastases of different primary tumors: a retrospective analysis. Kaplan JG, DeSouza TG, Farkash A, Shafran B, Pack D, Rehman F, Fuks J, Portenoy R. Leptomeningeal metastases: comparison of clinical features and laboratory data of solid tumors, lymphomas and leukemias. Epub 2020 Jun 17.Ther Adv Hematol. J Neurol Neurosurg Psychiatry 1988;51:142-5.9. E-mail: sdlxlwj@126.com This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License (Clinical experiences, intrathecal dexamethasone and methotrexate, neoplastic meningitisNeoplastic meningitis (NM) is the leptomeningeal dissemination of metastatic tumors; a devastating complication from solid tumors. Consort diagram for Children’s Oncology Group AALL0232. DC, dexamethasone plus Capizzi escalating-dose methotrexate… (A) Event-free survival (EFS) and overall survival (OS) for eligible, evaluable enrolled participants.… (A) Event-free survival (EFS) comparisons by methotrexate regimen, all randomly assigned participants. Borowitz MJ, Wood BL, Devidas M, Loh ML, Raetz EA, Salzer WL, Nachman JB, Carroll AJ, Heerema NA, Gastier-Foster JM, Willman CL, Dai Y, Winick NJ, Hunger SP, Carroll WL, Larsen E.Blood. (A) Overall survival (OS) comparisons by treatment regimen, randomly assigned participants age 1 to 9 years. 111Indium-diethylenetriamine pentaacetic acid cerebrospinal fluid flow studies predict distribution of intrathecally administered chemotherapy and outcome in patients with leptomeningeal metastases. The 5-year EFS rates for C-MTX and HD-MTX were 82.8 ± 1.7% and 84.9 ± 1.6%, respectively. COVID-19 is an emerging, rapidly evolving situation. Br J Haematol 2013;161:607.22. © 2016 by American Society of Clinical Oncology. Subjects in the palliative care group received supportive treatments in hospital or at home, according to the families’ determination based on the pain of lumber puncture or economic reasons.Intrathecal injections were conducted as follows: use of intravenous mannitol 250 mL was 20 min before lumbar puncture and remained throughout the process of lumber puncture. The 5-year EFS and OS rates were 75.3 ± 1.1% and 85.0 ± 0.9%, respectively. Neurology 1998;50:438-44.26. Theodore WH, Gendelman S. Meningeal carcinomatosis. CONCLUSION: High-dose methotrexate is superior to Capizzi methotrexate for the treatment of high-risk B-acute lymphoblastic leukemia, with no increase in acute toxicity. 2020 May 14;41(5):399-404. doi: 10.3760/cma.j.issn.0253-2727.2020.05.007.Salzer WL, Burke MJ, Devidas M, Dai Y, Hardy KK, Kairalla JA, Gore L, Hilden JM, Larsen E, Rabin KR, Zweidler-McKay PA, Borowitz MJ, Wood B, Heerema NA, Carroll AJ, Winick N, Carroll WL, Raetz EA, Loh ML, Hunger SP.J Clin Oncol. Arch Neurol 1981;38:696-9.5. Just as in Glantz’s study, an age > 50, performance status ≤ 70%, primary tumor (lung cancer, malignant melanoma), and lack of cytological response present negative prognostic factors.Methotrexate is a folate anti-metabolite and a S-phase specific cytotoxin with a CSF half-life of 4.5-8.0 h.In conclusion, intrathecal dexamethasone and methotrexate are a safe and effective therapy. Most of the patients’ discomfort was relieved in 3-4 weeks in IT DXM and MTX group with the decreased use of painkillers.

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