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A Psychological Perspective on the Association between Critical Care Resource Availability and Emotional Wellness during the COVID-19 Pandemic Search for other works by this author on: VfendVoriconazole concentrations in the cerebrospinal fluid and brain tissue of guinea pigs and immunocompromised patientsDetermination of vitreous, aqueous, and plasma concentration of orally administered voriconazole in humansPharmacokinetic/pharmacodynamic profile of voriconazoleVoriconazole, a novel wide-spectrum triazole: oral pharmacokinetics and safetyThe pharmacokinetics and safety of intravenous voriconazole—a novel wide-spectrum antifungal agentIdentification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazoleEPARs for authorised medicinal products for human use. Enzyme induction can lead to either increased drug exposure (in the case of a prodrug) and decreased drug exposure, with subsequent decreased effect. Lausanne, Other / Non US Polymorphisms of CYP2C9 and CYP2C19 may play a clinically relevant role, whereas polymorphisms of CYP3A4 are not considered clinically relevant. Treatment BV can be treated with over the counter topical (vaginal) or oral antibiotics such as over the counter bacterial skin infection treatment metronidazole or clindamycin. Search for other works by this author on: Finally, addressing the problem of drug-drug interactions is a multidisciplinary task, with the goal of minimizing unwanted adverse effects while optimizing patient care.We thank Dr. Peter Donnelly for his thoughtful review of this article.Oxford University Press is a department of the University of Oxford. Search results for “sporanox” Available at: Enhanced bioavailability of itraconazole in hydroxypropyl-β-cyclodextrin solution versus capsules in healthy volunteersProtein binding of itraconazole and fluconazole in patients with chronic renal failureItraconazole. They are a substrate for and inhibitors of cytochrome P450 (CYP450) enzymes, as well as inhibitors of membrane transporters such as P-glycoprotein (P-gP). Limitations Of Use. A metabolically based drug interaction: in vivo studiesCoadministration of voriconazole and phenytoin: pharmacokinetic interaction, safety, and tolerationInduction of voriconazole metabolism by rifampin in a patient with acute myeloid leukemia: importance of interdisciplinary communication to prevent treatment errors with complex medicationsLopinavir/ritonavir reduces lamotrigine plasma concentrations in healthy subjectsPharmacokinetics of voriconazole and cytochrome P450 2C19 genetic statusSafety of voriconazole in a patient with CYP2C9*2/CYP2C9*2 genotypeThe hydroxylation of omeprazole correlates with S-mephenytoin metabolism: a population studyEffects of the antifungal agents on oxidative drug metabolism: clinical relevanceOatp2 mediates bidirectional organic solute transport: a role for intracellular glutathioneInteractions of azole antifungal agents with the human breast cancer resistance protein (BCRP)Reduced oral itraconazole bioavailability by antacid suspensionInteraction of azoles with rifampin, phenytoin, and carbamazepine: in vitro and clinical observationsEffect of simultaneous didanosine administration on itraconazole absorption in healthy volunteersItraconazole comedication increases systemic levels of inhaled fluticasone in lung transplant recipientsGrapefruit juice decreases the systemic availability of itraconazole capsules in healthy volunteersItraconazole drastically increases plasma concentrations of lovastatin and lovastatin acidDifferent effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatinEffect of omeprazole on the pharmacokinetics of itraconazoleItraconazole and hydroxyitraconazole serum concentrations are reduced more than tenfold by phenytoinDrug interaction assessment following concomitant administration of posaconazole and phenytoin in healthy menEvaluation of the pharmacokinetics of posaconazole and rifabutin following co-administration to healthy menEffect of rifampicin on the pharmacokinetics of itraconazole in normal volunteers and AIDS patientsVoriconazole and sirolimus coadministration after allogeneic hematopoietic stem cell transplantationOpposite effects of short-term and long-term St John's wort intake on voriconazole pharmacokineticsItraconazole affects single-dose terfenadine pharmacokinetics and cardiac repolarization pharmacodynamicsThe effect of ingestion time interval on the interaction between itraconazole and triazolamOral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazoleSevere vincristine neurotoxicity with concomitant use of itraconazoleItraconazole-related increased vincristine neurotoxicity: case report and review of literatureAggravation of vincristine-induced neurotoxicity by itraconazole in the treatment of adult ALLSevere vincristine toxicity in combination with itraconazoleItraconazole-enhanced vincristine neurotoxicity in a child with acute lymphoblastic leukemiaPotentiation of vincristine toxicity by itraconazole in children with lymphoid malignanciesVincristine toxicity in five children with acute lymphoblastic leukaemiaVincristine-itraconazole interaction: cause for increasing concernEnhanced vincristine neurotoxicity from drug interactions: case report and review of literatureThe effect of intravenous and oral fluconazole on the pharmacokinetics and pharmacodynamics of intravenous alfentanilVoriconazole, but not terbinafine, markedly reduces alfentanil clearance and prolongs its half-lifeA fluconazole/amitriptyline drug interaction in three male adultsEffect of itraconazole on the pharmacokinetics of atorvastatinPlasma concentrations of inhaled budesonide and its effects on plasma cortisol are increased by the cytochrome P4503A4 inhibitor itraconazoleIatrogenic adrenal insufficiency as a side-effect of combined treatment of itraconazole and budesonideCabergoline plasma concentration is increased during concomitant treatment with itraconazoleItraconazole increases but grapefruit juice greatly decreases plasma concentrations of celiprololInteraction between cyclosporine and fluconazole in renal allograft recipientsUnpredictable cyclosporin-fluconazole interaction in renal transplant recipientsEvaluation of the drug interaction between intravenous high-dose fluconazole and cyclosporine or tacrolimus in bone marrow transplant patientsBeneficial pharmacokinetic interaction between cyclosporine and itraconazole in renal transplant recipientsPharmacokinetic evaluation of the drug interaction between intravenous itraconazole and intravenous tacrolimus or intravenous cyclosporin A in allogeneic hematopoietic stem cell transplant recipientsEffect of oral posaconazole on the pharmacokinetics of cyclosporine and tacrolimusEffect of voriconazole on the pharmacokinetics of cyclosporine in renal transplant patientsRenal interaction between itraconazole and cimetidineEffect of voriconazole on the pharmacokinetics of diclofenacPharmacokinetic interaction between voriconazole and efavirenz at steady state in healthy male subjectsPharmacokinetic interactions of efavirenz and voriconazole in healthy volunteersPharmacokinetics and tolerability of voriconazole and a combination oral contraceptive co-administered in healthy female subjectsItraconazole greatly increases plasma concentrations and effects of felodipineEffect of fluconazole on plasma fluvastatin and pravastatin concentrationsEffects of fluconazole and fluvoxamine on the pharmacokinetics and pharmacodynamics of glimepiridePharmacokinetic interaction between voriconazole and methadone at steady state in patients on methadone therapyEffect of route of administration of fluconazole on the interaction between fluconazole and midazolamInteraction between fluconazole and midazolam in intensive care patientsThe effects of the systemic antimycotics, itraconazole and fluconazole, on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam150 mg fluconazole does not substantially increase the effects of 10 mg midazolam or the plasma midazolam concentrations in healthy subjectsEffect of itraconazole and terbinafine on the pharmacokinetics and pharmacodynamics of midazolam in healthy volunteersThe area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicinMidazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazoleEffect of posaconazole on cytochrome P450 enzymes: a randomized, open-label, two-way crossover studyEffect of voriconazole on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolamRitonavir-dependent fluconazole boosting of nelfinavir: a report of three casesPharmacokinetic study of the interaction between itraconazole and nevirapineInfluence of fluconazole on the pharmacokinetics of omeprazole in healthy volunteersEffect of fluconazole on the disposition of phenytoinSteady-state pharmacokinetic and safety profiles of voriconazole and ritonavir in healthy male subjectsPotent cytochrome P450 2C19 genotype-related interaction between voriconazole and the cytochrome P450 3A4 inhibitor ritonavirPharmacokinetics of lower doses of saquinavir soft-gel caps (800 and 1200 mg twice daily) boosted with itraconazole in HIV-1-positive patientsSimvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazoleFluconazole therapy in transplant recipients receiving FK506Itraconazole prophylaxis in lung transplant recipients receiving tacrolimus (FK 506): efficacy and drug interactionEffect of voriconazole on the pharmacokinetics and pharmacodynamics of zolpidem in healthy subjectsEffect of itraconazole on the single oral dose pharmacokinetics and pharmacodynamics of alprazolamEffects of itraconazole on the steady-state plasma concentrations of bromperidol and reduced bromperidol in schizophrenic patientsHistamine H2-receptor antagonists have no clinically significant effect on the steady-state pharmacokinetics of voriconazolePotential interaction between itraconazole and clarithromycinCyclophosphamide metabolism is affected by azole antifungalsThe cytochrome P450 3A4 inhibitor itraconazole markedly increases the plasma concentrations of dexamethasone and enhances its adrenal-suppressant effectVoriconazole and fluconazole increase the exposure to oral diazepamThe effect of the antimycotic itraconazole on the pharmacokinetics and pharmacodynamics of diazepamInhibition of the metabolism of etizolam by itraconazole in humans: evidence for the involvement of CYP3A4 in etizolam metabolismEffect of voriconazole and fluconazole on the pharmacokinetics of intravenous fentanylThe CYP 3A4 inhibitor itraconazole has no effect on the pharmacokinetics of i.v.

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