neuroleptic tenormin

Therapy with these agents should be administered cautiously in patients with a history of priapism, conditions that may predispose them to priapism (e.g., sickle cell anemia, multiple myeloma, leukemia, thalassemia), or anatomical deformations of the penis (e.g., angulation, cavernosal fibrosis, Peyronie's disease).

Neuroleptic agents may precipitate symptoms of tardive dyskinesia (TD), a syndrome consisting of rhythmic involuntary movements variously involving the tongue, face, mouth, lips, jaw, and/or trunk and extremities, following chronic use of at least several months but often years. Electrolyte disturbances such as hypokalemia and hypomagnesemia may augment the prolongation effect of these agents on the QT interval and should be corrected prior to institution of therapy.

Clinical manifestations of NMS include hyperpyrexia, muscle rigidity, altered mental status and autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac arrhythmias). 20. Therapy with these drugs should be administered cautiously in patients with a history of seizures or other predisposing factors, such as head trauma, CNS abnormalities, and alcoholism.Moderate Potential Hazard, High plausibility. mellaril. Applies to: Breast Cancer, HyperprolactinemiaThe chronic use of neuroleptic agents can cause persistent elevations in prolactin levels due to antagonism of dopamine D2 receptors. Not only might two substances interact with each other, but they may also interact with whatever anomalies you may have going on with your personal biochemistry. A causal relationship with antipsychotic use has not been established. Applies to: Altered Consciousness, Respiratory ArrestThe use of neuroleptic agents is contraindicated in comatose patients and patients with severe central nervous system depression. Applies to: ParkinsonismThe use of neuroleptic agents is associated with pseudo-parkinsonian symptoms such as akinesia, bradykinesia, tremors, pill-rolling motion, cogwheel rigidity, and postural abnormalities including stooped posture and shuffling gait. A single copy of these materials may be reprinted for noncommercial personal use only. Patients with diabetes should be monitored for worsening control of blood glucose when treated with these agents. Squire DL. anticonvulsant mood stabalizer. Neuroleptic agents should not be given to patients with active NMS and should be immediately discontinued if currently being administered in such patients. Until further data are available, therapy with neuroleptic agents should be administered cautiously in patients with a previously detected breast cancer. Galactorrhea, amenorrhea, gynecomastia, and impotence have been reported in patients receiving prolactin-elevating compounds; however, the clinical significance of elevated serum prolactin levels is unknown for most patients. Reiter S, Adler L, Angrist B, Corwin J, Rotrosen J. TBG levels were not altered in any patient, while TSH increased in 0.4% (10/2386) of patients, some of whom required thyroid replacement therapy. Why Are Dementia Patients Getting Risky Psychiatric Drugs? At the first sign of a clinically significant decline in white blood cells, discontinuation of atypical antipsychotic therapy should be considered in the absence of other causative factors, and the patient closely monitored for fever or other signs and symptoms of infection.Moderate Potential Hazard, Moderate plausibility. Additional signs may include elevated creatine phosphokinase, myoglobinuria, and acute renal failure. Applies to: NeutropeniaCases of leukopenia, neutropenia, and agranulocytosis have been reported with the use of atypical antipsychotic agents. During the 26 week open-label clinical trial, one child with a reported history of hypertension experienced a hypertensive crisis. Stotter Cuddy ML. Select one or more newsletters to continue. Therapy with neuroleptic agents should be administered cautiously in patients with significant liver disease. The onset is usually 1 to 2 weeks following initiation of therapy or an increase in dosage. 5.14 Hyperprolactinemia. In controlled trials, treatment with some atypical antipsychotic drugs was also associated with an increased risk of cerebrovascular adverse events (e.g., stroke, transient ischemic attack), including fatalities, in elderly patients with dementia- related psychosis. 1.

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