nitroglycerin iv dose for uterine relaxation alesse

Name must be less than 100 characters Therapeutic indications for GTN range from facilitating external cephalic version, difficult vaginal or cesarean section delivery, and manual exploration of the uterus, to its use as a tocolytic. Complete muscular relaxation was obtained at a concentration of 25-50 µg/ml.

2001 Apr;29(2):163-77. doi: 10.1177/0310057X0102900211.Leszczyńska-Gorzelak B, Laskowska M, Marciniak B, Oleszczuk J.Leszczynska-Gorzelak B, Laskowska M, Marciniak B, Oleszczuk J.Int J Gynaecol Obstet. In our experience, the administration of 50-100 micro gram of nitroglycerin intravenously or 800 micro gram sublingually has not resulted in decreased maternal blood pressure consistently, or even frequently, in urgent clinical settings. Anaesth Intensive Care. Author information: (1)Department of Obstetric and Gynecology, University Hospital, Uppsala, Sweden. The intravenous regimen of GTN required to obtain the desired degree of uterine relaxation is extremely variable; intravenous bolus doses of 50 micrograms to 500 micrograms GTN with up to three repeated injections of 50 micrograms to 250 micrograms have been reported.

BACKGROUND: To investigate the effect of nitroglycerin in vitro and in vivo on human uterine …

For its rapid onset and short duration, intravenous nitroglycerin (NTG) is commonly used for this purpose.

Dr. Shin et al. doi: 10.1097/00006254-199809000-00023. doi: 10.1097/00006254-199809000-00023. 2000;28(3):232-42. doi: 10.1515/JPM.2000.032.Arch Gynecol Obstet.

Other methods of GTN administration include transdermal patches and sublingual spray. Intravenous nitroglycerin has been used to relax the uterus during manual extraction of retained placenta and to permit replacement of a contracted, completely prolapsed, inverted uterus. This may be a result of the scarcity of vascular endothelium present in these preparations.

Intravenous nitroglycerin for rapid uterine relaxation. Uterine Relaxation (for External Cephalic Version): 50 mcg IV direct every 90 seconds; repeat as required up to a maximum of 500 mcg over 15 minutes; or. In vitro nitroglycerin induced a dose-dependent inhibition of spontaneous as well as oxytocin-induced myometrial contractile activity.

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Data from human and experimental animal research indicate that nitric oxide (NO), a novel messenger, formed during the nitric oxide synthase-catalyzed oxidation of L-arginine to L-citrulline, is involved in maintaining normal uterine tone during gestation. Our concern, however, is that the authors compared uterine contractile response to …

I suspect that the anxiety engendered by rapid interventions such as maternal position changes, increased intravenous fluid administration, application of supplemental oxygen, and summoning the obstetrician ameliorate the vasodilatory effects of the nitroglycerin. : Effect of nitroglycerin on pregnant uterine muscle in vitro: A dose-response study. METHODS: We evaluated the effect of NTG 200 microg on uterine relaxation in 14 parturients who required rapid uterine relaxation during cesarean delivery from October 2010 to March 2011. By continuing to use our website, you are agreeing to found a dose-dependent reduction of contractility in isolated human uterine muscle segments exposed to nitroglycerin in vitro, but the mean dose to abolish spontaneous contractions was 4.5 x 10 sup -4 M (250 micro gram in the 12 ml bath), far exceeding commonly used clinical doses. These include tetanic uterine contraction, extraction of a breech twin, or manual extraction of placenta. Unable to load your delegates due to an error Anesth Analg 1994; 78:S391.Redick LF, Bell EA, Livingston E: Sublingual aerosol nitroglycerin for uterine relaxation in attempted external version.

Several recent case reports and case series have described the effective use of nitroglycerin (GTN), a NO donor compound, antenatally, intrapartum, and postpartum for acute uterine relaxation. Division of Women's Anesthesia; Duke University Medical Center; Box 3094; Durham, North Carolina 27710 However, clinical trials with use of objective methods of evaluating uterine tone and comparing GTN to other tocolytic agents are required before widespread use in advocated. Results. COVID-19 is an emerging, rapidly evolving situation. Nitroglycerin relaxes smooth muscle cells by releasing nitric oxide and is regularly used to induce prompt uterine relaxation in cases of obstetric emergency . This is in contrast to our recent trial using nitroglycerin spray in the setting of elective external version of breech position.

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