nocturnal enuresis treatment hydrochlorothiazide

The collected data were analyzed using SPSS software (Statistical Package for the Social Sciences, version 18.0, SPSS Inc, Chicago, Illinois, USA) and descriptive statistics for frequency determination. The number of samples was calculated with regard to the prevalence of NE and IHC (α = 5%, β = 20%).Primary monosymptomatic nocturnal enuresis was defined as follow: 1) NE: repeated involuntary voiding of urine in bed, at least twice a week for at least 3 consecutive months in a child of more than 5 years of age, 2) primary enuresis: children who have never gained control over urination, 3) monosymptomatic nocturnal enuresis: children without daytime urinary symptoms (A meticulous history taking (especially with respect to fluid intake at night and pattern of nocturnal enuresis and daytime symptoms), clinical examination, necessary lab tests (blood and urinary chemistry tests and urine cultures), abdominal ultrasonography and voiding cystourethrograms were done.our exclusion criteria were: boys with secondary nonidiopathic hypercalciuria, anatomical problems, history of diabetes insipidus, diabetes mellitus and chronic renal disease, impaired kidney function, UTIs and history of recurrent UTIs, abnormal Urinalysis (UA), history of unusual fluid intake especially at night, small bladder for age and urinary tract and renal abnormality.After obtaining written consents, patients were divided into two equal groups (intervention and control groups) using simple random sampling and demographic, clinical and perinatal data (age, birth weight, mother’s age at birth, gestational age, maternal education, household incomes, marital status, siblings, type of delivery and history of jaundice at birth) were recorded.The study coordination center at the Arak University Hospital (Amir Kabir Hospital) randomly assigned participating patients to one of the two groups. Antidiuretic effect of hydrochlorothiazide in lithium-induced nephrogenic diabetes insipidus is associated with upregulation of aquaporin-2, Na-Cl co-transporter, and epithelial sodium channel. von Gontard A, Effects of thiazide on the expression of TRPV5, calbindin-D28K, and sodium transporters in hypercalciuric rats. To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. View Show abstract and Hoebeke P, Long, Clive G. et al. Siddique, Rizwana Emporiadou MN, A placebo-controlled trial of the effects of hydrochlorothiazide on nocturnal enuresis. This data will be updated every 24 hours.Your email address will be used in order to notify you when your comment has been reviewed by the moderator and in case the author(s) of the article or the moderator need to contact you directly.Please list any fees and grants from, employment by, consultancy for, shared ownership in or any close relationship with, at any time over the preceding 36 months, any organisation whose interests may be affected by the publication of the response. Merks BT, Burger H, Willemsen J, van Gool JD, de Jong TP. However, in 21 patients the dose was increased to 2 mg/kg/day.The mean age of boys in the HCT group was 7.9 ± 2.09 and in the control group was 8.2 ± 1.23 years (P = 0.21). Dolley, Olga Nevéus T, (Based on our findings, children who became normocalciuric after receiving HCT had significant PMNE clinical response. P values less than 0.05 were considered significant. Clozapine-induced enuresis is probably under-reported owing to the embarrassing nature of this side-effect.To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Chang HR, 4. Moreover, Mann-Whitney and Wilcoxon tests (due to nonnormal distribution of the data) were used to compare the mean monthly wet-night episodes of the groups and assess clinical response to treatment in each group during the 4 months of treatment, respectively. Those with suspicious complaints were referred to a pediatrician. Siddique, Rizwana Ioannidis E, Kersten FF, This disorder may persist through adolescence and adulthood causing great distress (Idiopathic Hypercalciuria (IHC) can be one of the causes of urinary problems in children (According to a recent observation in 2010 by Raes et al. Wang H, Brain metabolite alterations in children with primary nocturnal enuresis using proton magnetic resonance spectroscopy. Banyard, Ellen Does hydrochlorothiazide prevent recurrent urinary tract infection in children with idiopathic hypercalciuria? van der Eerden BC, The Standardization of Terminology of Lower Urinary Tract Function in Children and Adolescents: Report from the Standardisation Committee of the International Children’s Continence Society. The findings of Alawwa et al. HjälmÃ¥s K, Find out more about sending to your Kindle. Kim S, Park SJ, Kim JH, Shin JI. Then enter the ‘name’ part of your Kindle email address below. Hoebeke P, Aivazis VT, Conclusions: Hydrochlorothiazide can be used as an effective and safe therapeutic option for treatment of primary monosymptomatic nocturnal enuresis. The calcium to cratinine ratio in urine was being measured for all children in the visits made at the end of each month (by pediatrician) and increasing thiazide’s dose to 2 mg/kg/day for the children who did not become normocalciuric (Patients absent at follow-up visits, noncompliant in drug consumption, those with noncooperative parents, children on HCT who did not become normocalciuric despite 2 mg/kg/day of HCT, patients developing UTIs, those with side effects of HCT consumption were excluded from the study and replaced by similar cases.

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