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TdPs können aber auch in Kammerflimmern übergehen und zum plötzlichen Herztod führen. Wernicke JF, Faries D, Girod D, Brown J, Gao H, Kelsey D, et al. Haverkamp W, Haverkamp F, Breithard G: Medikamenteninduzierte QT-Verlängerung und Torsade de pointes. An 81-year-old lady was admitted to our hospital with a 3-year history of noninfective diarrhoea and recurrent syncopal events over the last 3 months. Charakteristische Symptome der meist selbstlimitierenden TdPs sind Krampfanfall, Schwindel und Synkopen. Eine dosisabhängige Verlängerung der QT-Zeit ist zwar insbesondere für die klassischen Antipsychotika und trizyklischen Antidepressiva bekannt, bedeutet aber, wie insbesondere das Beispiel von Sertindol zeigt, nicht zwangsläufig auch das Vorliegen eines erhöhten torsadogenen Potenzials (Die Bestimmung des QT-Intervalls ist vor allem dann schwierig, wenn die Amplitude der T-Welle niedrig und daher das Ende der T-Welle schwer abgrenzbar ist. J Med Toxicol 2008; 4: 18–20. Vieweg WV, Wood MA: Tricyclic antidepressants, QT interval prolongation, and torsade de pointes. We report a case of concealed LQTS manifesting under anesthesia and its subsequent perioperative course. Psychosomatics 2000; 41: 63–5. Epilepsia 2009; 50: 1841–9. Hui WK, Mitchell LB, Kavanagh KM, Gillis AM, Wyse DG, Manyari DE, et al. Kang UG, Kwon JS, Ahn YM, Chung SJ, Ha JH, Koo YJ, et al. Ann Gen Psychiatry 2005; 4(1): 1. doi: 10.1186/744–859X-4–1. Key Words. Llorca PM, Pere JJ: Leponex®, 10 ans après – Une revue clinique [Leponex, 10 years after—a clinical review] [Article in French]. Curr Drug Abuse Rev 2008; 1: 297–302. Am J Med Sci 1995; 309: 315–6. Pharmacotherapy 2001; 21: 871–83. 2013 Apr 26;5(4):87-93. doi: 10.4330/wjc.v5.i4.87.Nagele P, Pal S, Brown F, Blood J, Miller JP, Johnston J.Anesthesiology. Lower heart rates also result in a longer QT interval. Simpson D, Plosker GL: Spotlight on atomoxetine in adults with attention-deficit hyperactivity disorder. : Is valproate promising in cardiac fatal arrhythmias? Ciszowski K, Szpak D, Jenner B: The influence of carbamazepine plasma level on blood pressure and some ECG parameters in patients with acute intoxication. Züchner H: QT-Verlängerung und Torsade de pointes-Tachykardie bei Therapie mit Maprotilin. J Clin Psychopharmacology 2009; 29: 9–15. Dr. Wittmann hielt Vorträge für AstraZeneca, GlaxoSmithKline, Lilly, Pfizer und Eisai, er erhielt Beraterhonorare von Bristol-Myers Squibb und Honorarae für Publikationen von Servier und nahm als Prüfarzt bei klinisch-pharmakologischen Studien teil für Servier, AstraZeneca, Janssen-Cilag, Pfizer und Lilly.Prof. Anstatt die am EKG-Streifen abgelesene (oder errechnete) QT-Zeit mit einem frequenzbezogenen Normalwert zu vergleichen, kann man auch den umgekehrten Weg gehen und sie als frequenzkorrigierte QT-Zeit (QTc) angeben, die der QT … Berlin 2010: 497–841. For risk of sudden cardiac death, "borderline QTc" in males is 431–450 ms; and, in females, 451–470 ms. An "abnormal" QTc in … Sharma ND, Rosmann HS, Padhi ID, Tisdale JE: Torsades de pointes associated with intravenous haloperidol in critically ill patients. Br J Clin Pharmacol 2008; 66: 396–404. Sigmoidoscopy … J Med Toxicol 2008; 4: 101–5. Poluzzi E, Raschi E, Moretti U, De Ponti F: Drug-induced torsades de pointes: data mining of the public version of the FDA Adverse Event Reporting System (AERS). Wien Klin Wochenschr 2008; 120: 128–35. Adverse Drug React Toxicol Rev 2002; 21: 189–203. [Antipsychotica-induced QT-prolongation]. Gajwani P, Pozuelo L, Tesar GE: QT interval prolongation associated with quetiapine (Seroquel) overdose. Dr. Haen gibt Votragstätigkeit, Mitarbeit in wissenschaftlichen Beiräten und Teilnahme als Prüfarzt an klinischen Studien im Auftrag von Janssen-Cilag, Lilly, Pfizer, GlaxoSmithKline, AstraZeneca, Bristol-Myers Squibb, Otsuka, Bayer Vital, Servier und Südmedica GmbH an.QTc Prolongation by Psychotropic Drugs and the Risk of Torsade de PointesThe English version of this article is available online:Um Artikel, Nachrichten oder Blogs kommentieren zu können, müssen Sie

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