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All the analyses are based on the intention-to-treat principle.Among the 145 patients who were excluded from the trial, several had more than one reason for exclusion.

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The median time until the first exacerbation was 202 days in the metoprolol group and 222 days in the placebo group. Jetzt gibt es endlich eine wunderbare und alternative Lösung dieses Problems, die Sie seit langem von hunderttausenden Varianten gesucht haben.

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Second, our trial population had moderate or severe COPD with a high prevalence of supplemental oxygen use and previous hospitalization for COPD.

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