oxybutynin for hot flashes reviews luvox

To determine whether oxybutynin chloride (oxybutynin) can diminish hot-flash activity in women with a history of breast cancer or in women who have a concern about taking estrogen for fear of breast cancer.I. Can oxybutynin be useful for some patients who are experiencing hot flashes and are unsuited for hormonal pharmacotherapy? To assess the impact of hot-flash activity on overall quality of life and to examine whether oxybutynin can diminish this impact on quality of life.OUTLINE: Patients are randomized into 1 of 4 groups.GROUP I (LOW-DOSE OXUBUTYNIN CHLORIDE): Patients receive lower dose oxybutynin chloride orally (PO) twice a day (BID) on days 8-49 in the absence of unacceptable toxicity.GROUP II (LOW-DOSE PLACEBO): Patients receive lower dose placebo PO BID on days 8-49 in the absence of unacceptable toxicity.GROUP III (HIGH-DOSE OXUBUTYNIN CHLORIDE): Patients receive lower dose oxybutynin chloride PO BID on days 8-14 and higher dose oxybutynin chloride on days 15-49 in the absence of unacceptable toxicity.GROUP IV (HIGH-DOSE PLACEBO): Patients receive lower dose placebo PO BID on days 8-14 and higher dose placebo on days 15-49 in the absence of unacceptable toxicity.Any of the following current (=< 4 weeks prior) or planned therapies:History of any of the following contraindications to oxybutynin:

review of such patients to determine the effect of oxybutynin in treating hot flashes and to observe the side effects of the drug in these patients. This randomized phase III trial studies how well oxybutynin chloride works in managing hot flashes in patients who are not candidates for, or not interested in hormone replacement therapy. The least squares (LS) mean was estimated from a mixed-effects model with repeated measures (MMRM) that included low dose oxybutynin, weeks 1-7, no current aromatase inhibitor, age group 18-49, no tamoxifen, hot flash symptom duration < 9 months, and 4-9 hot flashes/day as fixed effects, and participant and error as random effects. Roberto A Leon-Ferre, Paul J Novotny, Eric G Wolfe, Stephanie S Faubion, Kathryn J Ruddy, Daniel Flora, Christopher S R Dakhil, Kendrith M Rowland, Mark L Graham, Nguyet Le-Lindqwister, Thomas J Smith, Charles L Loprinzi, Oxybutynin vs Placebo for Hot Flashes in Women With or Without Breast Cancer: A Randomized, Double-Blind Clinical Trial (ACCRU SC-1603), JNCI Cancer Spectrum, Volume 4, … This is a count, so it can range from 0 to infinity.Average change in Hot Flash Score from Week 1 to Week 7 Comparing Low Dose Oxybutynin to Placebo.

A placebo-controlled, randomized study is being developed to look more closely at the effectiveness of oxybutynin in reducing hot flashes. This trial is evaluating lower doses of oxybutynin with the goal of determining if they are efficacious with less side effects.I. is scored from 0 to 10 with higher values being worse symptoms. The hot flash activity will be measured by the weekly average hot flash score (Sloan JA, et. Design: A prospective database of all patients treated for hot flashes was started in July 2004 and was retrospectively analyzed as of March 2006. You have reached the maximum number of saved studies (100).Please remove one or more studies before adding more.Patients receive lower dose oxybutynin chloride PO BID on days 8-49 in the absence of unacceptable toxicity.Patients receive lower dose placebo PO BID on days 8-49 in the absence of unacceptable toxicity.Patients receive lower dose oxybutynin chloride PO BID on days 8-14 and higher dose oxybutynin chloride on days 15-49 in the absence of unacceptable toxicity.Patients receive lower dose placebo PO BID on days 8-14 and higher dose placebo on days 15-49 in the absence of unacceptable toxicity.Average change in hot flash activity score from baseline to Week 7 for Low Dose Oxybutynin vs Placebo. HFRDIS Work item ("Work (work outside the home and housework)") Interference scores run from 0 to 10 with 0 being no interference and 10 being complete interference.The maximum grade for each type of toxicity will be recorded for each patient, and frequency tables will be reviewed to determine toxicity patterns within patient groups. II. Background: Hot flashes (HFs) negatively affect quality of life among perimenopausal and postmenopausal women.

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