pcsk9 inhibitors review article aldactone

Based on evidence from clinical trials, the 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) guidelines for the management of dyslipidemias now include the use of PCSK9i to very high-risk ASCVD patients who are not achieving treatment goals on a maximum tolerated dose of a statin and ezetimibe. Presented at the 67th Scientific Sessions of the American College of Cardiology (2018).Wiviott, S. D. et al. Evaluating bococizumab, a monoclonal antibody to PCSK9, on lipid levels and clinical events in broad patient groups with and without prior cardiovascular events: rationale and design of the studies of PCSK9 inhibition and the reduction of vascular events (SPIRE) lipid lowering and SPIRE cardiovascular outcomes trials. & Breslow, J. L. Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment. Efficacy and safety of alirocumab in high cardiovascular risk patients with inadequately controlled hypercholesterolaemia on maximally tolerated doses of statins: the ODYSSEY COMBO II randomized controlled trial.

Efficacy and safety of alirocumab versus ezetimibe in statin-intolerant patients, with a statin rechallenge arm: the ODYSSEY ALTERNATIVE randomized trial. Internet Explorer). Highlights of prescribing information: LIPITOR®. Ding, Q. et al. Cannon, C. P. et al. Maxwell, K. N., Fisher, E. A. Article highlights. Robinson, J. G. et al. Effect of evolocumab or ezetimibe added to moderate- or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: the LAPLACE-2 randomized clinical trial. Wasserman, S. et al. Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA part B): a randomised, double-blind, placebo-controlled trial. A. et al. Inflammatory and cholesterol risk in the FOURIER trial (further cardiovascular outcomes research with PCSK9 inhibition in patients with elevated risk). Wiviott, S. D. The effects of adding the CETP inhibitor anacetrapib to statin on urgent and routine revascularization: results from the HPS 3/TIMI 55-REVEAL trial.

The completion of two major clinical trials on PCSK9 inhibitors (PCSK9i), the FOURIER and the ODYSSEY outcome trials, has marked the beginning of a new era of lipid-lowering drugs. Reduction of low density lipoprotein-cholesterol and cardiovascular events with proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors and statins: an analysis of FOURIER, SPIRE, and the Cholesterol Treatment Trialists Collaboration. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials.

Wasserman, S. et al.

Soon after, studies uncovered the role of PCSK9 in the regulation of LDL-receptor recycling and identified loss-of-function variants of Monoclonal antibodies targeting PCSK9 can lower plasma LDL-cholesterol (LDL-C) levels by approximately 60%.In dedicated cardiovascular outcome trials, PCSK9 inhibitors significantly reduced the risk of major adverse cardiovascular events.This benefit was consistent in patients with a baseline LDL-C level <70 mg/dl, who achieved an LDL-C level of approximately 20 mg/dl, which is well below the current guideline-recommended targets.No offsetting safety concerns were reported in these trials over the timeframes studied.Get time limited or full article access on ReadCube.Varret, M. et al.

Based on evidence from clinical trials, the 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) guidelines for the management of dyslipidemias now include the use of PCSK9i to very high-risk ASCVD patients who are not achieving treatment goals on a maximum tolerated dose of a statin and ezetimibe.

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