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. Single 25-mg doses at bedtime or 6.25 to 12.5 mg taken three times daily will usually suffice. . Keep your medicine in a cool dry place where the temperature will stay below 30°C. 3.75 mg IM once monthly or 11.25 mg IM every 3 months in combination with supplemental iron therapy. improve the ability to exercise in adults with pulmonary arterial hypertension (high blood pressure in the vessels carrying blood to the lungs, causing shortness of … The average dose is 25 mg taken before retiring; however, 12.5 mg may be taken before meals and on retiring, if necessary.

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