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If the insulin dose is between 20 and 40 units daily, the patient may be placed directly on Micronase Tablets 5 mg daily as a single dose. Furthermore, loss of blood glucose control on diet alone may be transient, thus requiring only short-term administration of Micronase or other antidiabetic medications. When such drugs are withdrawn from a patient receiving Micronase, the patient should be observed closely for loss of control.Certain drugs tend to produce hyperglycemia and may lead to loss of control. Use of Micronase or other antidiabetic medications must be viewed by both the physician and patient as a treatment in addition to diet and not as a substitution or as a convenient mechanism for avoiding dietary restraint. If Micronase is used during pregnancy, it should be discontinued at least two weeks before the expected delivery date.Although it is not known whether glyburide is excreted in human milk, some sulfonylurea drugs are known to be excreted in human milk. Pg 3 of 11 Genomic-DNA-QC.v3.docx SAMPLE MANAGEMENT STANDARD OPERATING PROCEDURE 2.1 Load the gel according to the format listed below: a. In addition, the 2.5 mg contains aluminum oxide and FD&C Red No. Select one or more newsletters to continue. Available for Android and iOS devices. With chronic administration in Type II diabetic patients, the blood glucose lowering effect persists despite a gradual decline in the insulin secretory response to the drug. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. Measurement of glycosylated hemoglobin levels may be helpful in some patients.The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents. (See Store at controlled room temperature 20° to 25°C (68° to 77°F) [see USP]. This should be followed by a continuous infusion of a more dilute (10%) glucose solution at a rate which will maintain the blood glucose at a level above 100 mg/dL. Inactive ingredients: colloidal silicon dioxide, dibasic calcium phosphate, magnesium stearate, microcrystalline cellulose, sodium alginate, talc. The mechanism for this interaction is not known.A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. Multiple dose studies with Micronase in diabetic patients demonstrate drug level concentration-time curves similar to single dose studies, indicating no buildup of drug in tissue depots. If the drug is discontinued, and if diet alone is inadequate for controlling blood glucose, insulin therapy should be considered.Safety and effectiveness in pediatric patients have not been established.Elderly patients are particularly susceptible to the hypoglycemic action of glucose lowering drugs. The decrease of glyburide in the serum of normal healthy individuals is biphasic; the terminal half-life is about 10 hours. A one year study of diabetic patients treated with Micronase showed no reliable correlation between administered dose and serum drug level.The major metabolite of glyburide is the 4-transhydroxy derivative. In addition to the usual monitoring of urinary glucose, the patient's blood glucose must also be monitored periodically to determine the minimum effective dose for the patient; to detect primary failure, Short-term administration of Micronase may be sufficient during periods of transient loss of control in patients usually controlled well on diet.The usual starting dose of Micronase Tablets is 2.5 to 5 mg daily, administered with breakfast or the first main meal.

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