�eU��q�C~�/n�/��1�[����O~Tt���O����.֏��{��ߺ����X�Zt�eij^QXJ�+��j����ϻ�~8V���ٽi1�����2�z2!�h�&˓e̋P�~25�ӝ�W�BԂV&�״Cl�x�DHV7���4�g���i^"��a~��S��HT=��J1!��C�왚��"|JZº�襁%5״%@[�)�������{\w�LJ�3�h�W�ޭ������Q�����ŏo�������^qCB���� and i.m. Tonic-clonic status epilepticus (TCSE) is the most common neurological emergency and affects approximately 60000 patients each year in the US.
Phenytoin monitoring in status epilepticus in infants and children. Ideally, drugs used to treat this condition should be well tolerated … However, this is unlikely to have affected the estimated pharmacokinetic parameters.a) Mean (SD) plasma total phenytoin concentrations (µg mlMean (95% CI) plasma magnesium concentrations were 0.75 (0.66, 0.85), 0.88 (0.78, 0.99) and 0.71 (0.6, 0.83) mmol lMore children in the i.m.
Venous access was obtained by inserting Teflon cannulae ( JelcoA blood sample (0.4 ml) for measuring plasma concentrations of phenytoin and fosphenytoin was withdrawn at 5, 10, 15, 20, 25, 30, 40, 60 min, and 2, 4, 6, 8, 12, 24, 36, 48, 54, 60 and 72 h after phenytoin or fosphenytoin administration. COVID-19 is an emerging, rapidly evolving situation. Ideally, drugs used to treat this condition should be well tolerated when administered as rapid intravenous infusions and should not interfere with patients' state of consciousness or cardiovascular and respiratory functions. Unable to load your collection due to an error
<>
phenytoin, 16 (8/8) in the i.v. Wiley
The cannula was flushed with 1 ml sterile heparinized (20 IU mlAn additional blood sample (1.5 ml) obtained 0.3 h after phenytoin or 2 h after fosphenytoin loading dose administration was centrifuged (1500 A specifically designed proforma was used to record details of the convulsions (type, duration, lowest oxygen saturation and blood glucose during the seizure) and a 5‐min postictal evaluation of the level of consciousness, respiratory rate and transcutaneous oxygen saturation was performed in all children admitted to the unit [Seizures were considered to be abolished if they stopped within 30 min from the start of drug administration. Clipboard, Search History, and several other advanced features are temporarily unavailable. 3 0 obj
• Für Valproat liegen noch keine ausreichende Evidenz und keine Zulassung vor, es kann als i.v.
1998 Oct;13 Suppl 1:S15-8; discussion S30-2.
phenytoin has been reported [The children in this study also received other drugs (quinine, benzylpenicillin, chloramphenicol and other anticonvulsants) concurrently. x��]��6��n����н�e�))��<6������߇vOϸ����c�����PK"E6�.A&3ݔ�c�X/V��篪o�y���/~��o������귧O(�{ʪ��uW .j�W��۾�N��O�����'߽~����HEH������'�jԿ�2j�~}��IS�����>�eU��q�C~�/n�/��1�[����O~Tt���O����.֏��{��ߺ����X�Zt�eij^QXJ�+��j����ϻ�~8V���ٽi1�����2�z2!�h�&˓e̋P�~25�ӝ�W�BԂV&�״Cl�x�DHV7���4�g���i^"��a~��S��HT=��J1!��C�왚��"|JZº�襁%5״%@[�)�������{\w�LJ�3�h�W�ޭ������Q�����ŏo�������^qCB���� and i.m. Tonic-clonic status epilepticus (TCSE) is the most common neurological emergency and affects approximately 60000 patients each year in the US.
Because phenytoin is a standard clinical treatment for convulsive status epilepticus, we compared the efficacy of lamotrigine to that of phenytoin in a model of secondarily generalized convulsive status epilepticus in rats that responds to drug concentrations similar to those that have been reported to be clinically useful for this purpose. doi: 10.1177/0883073898013001051.Glauser T, Shinnar S, Gloss D, Alldredge B, Arya R, Bainbridge J, Bare M, Bleck T, Dodson WE, Garrity L, Jagoda A, Lowenstein D, Pellock J, Riviello J, Sloan E, Treiman DM.Epilepsy Curr. 1977 Aug;8(3):286-92. doi: 10.1055/s-0028-1091524.Pediatr Neurol. phenytoin sodium and i.v. stream
Pharmacokinetic and Pharmacodynamic Data Analysis System for the PCPhenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol co‐administrationRapid attainment of therapeutic phenytoin concentrations following administration of loading doses of fosphenytoin. Acute hypoxia has been reported to have no effect on the activity of hepatic cytochrome P450 enzymes in man [Overall, only 47% of the children had their seizures controlled.
Got something to say?