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• Patients on high dosage should be warned that they may develop photosensitivity in sunny weather and should avoid exposure to direct sunlight.Neuroleptic malignant syndrome (hyperthermia, rigidity, autonomic dysfunction and altered consciousness) may occur with any neuroleptic (see section 4.4).Intolerance to glucose, hyperglycaemia (see section 4.4)Drug withdrawal syndrome neonatal (see section 4.6) – Frequency not known.Reporting suspected adverse reactions after authorisation of the medicinal product is important. PLEASE ENABLE JAVASCRIPT IN YOUR INTERNET OPTIONS. Severe extrapyramidal dyskinesias may occur.If the patients is seen sufficiently soon (up to 6 hours) after ingestion of a toxic dose, gastric lavage may be attempted. Call Rheumatologist & researcher, University of Otago, WellingtonQuality and Performance Manager, Hastings Health CentreThe material on this website is provided for educational purposes only, and is not to be used for medical advice, diagnosis or treatment. • Type I hypersensitivity reactions such as angioedema and urticaria. If the clinical situation permits, medical and laboratory evaluations (e.g. Ask your doctor if you are unsure why it has been prescribed for you.It may slow your reactions and make you feel drowsy. If you would like to reproduce any of this information, see

It should be avoided in patients known to be hypersensitive to phenothiazines or with a history of narrow angle glaucoma or agranulocytosis.Close monitoring is required in patients with epilepsy or a history of seizures, as phenothiazines may lower the seizure threshold.As agranulocytosis has been reported, regular monitoring of the complete blood count is recommended. Severe dystonic reactions usually respond to procyclidine (5-10mg) or orphenadrine (20-40mg) administered intramuscularly or intravenously. • Acute dystonia or dyskinesias, including oculogyric crisis, usually transitory are commoner in children and young adults, and usually occur within the first 4 days of treatment or after dosage increases. Prochlorperazine is extensively bound to plasma proteins, widely distributed in the body (it crosses the blood/brain barrier) and its metabolites cross the placental barrier and are excreted in milk. • Hyperprolactinaemia which may result in galactorrhoea, gynaecomastia, amenorrhoea and impotence. This could possibly happen with Prochlorperazine. Common side effects include sleepiness, blurry vision, low blood pressure, and dizziness. We're here to provide information and support.We won't give up until everyone experiencing a mental health problem gets support and respect.Together with our 20 local Minds in Wales we’re committed to improving mental health in this country. However, it may be combined with antidepressant therapy to treat those conditions in which depression and psychosis coexist.Because of the risk of photosensitisation, patients should be advised to avoid exposure to direct sunlight.To prevent skin sensitisation in those frequently handling preparations of phenothiazines, the greatest care must be taken to avoid contact of the drug with the skin (see section 4.8).It should be used with caution in the elderly, particularly during very hot or very cold weather (risk of hyper-, hypothermia).The elderly are particularly susceptible to postural hypotension.Prochlorperazine should be used cautiously in the elderly owing to their susceptibility to drugs acting on the central nervous system and a lower initial dosage is recommended.

• Syndrome of inappropriate antidiuretic hormone secretion (SIADH). It is also extensively metabolised in the liver and is excreted in the urine and bile. Phone 0845 372 7101 for help-1- 11503013-10 Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. Neuroleptic jaundice has the biochemical and other characteristics of obstructive jaundice and is associated with obstruction of the canaliculi by bile thrombi; the frequent presence of an accompanying eosinophilia indicates the allergic nature of this phenomenon. • Respiratory depression is possible in susceptible patients.Jaundice, usually transient, occurs in a very small percentage of patients taking neuroleptics.

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