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New York, NY: Pharmacia and Upjohn Company;2006 May.Pregnancy Category C is given to medicines that have not been adequately studied in pregnant humans but have caused fetal harm in animal studies. Prostin E2 Vaginal Suppository, an oxytocic, contains dinoprostone as the naturally occurring prostaglandin E2 (PGE2). This information—including product information—is intended only for residents of the United States.

In all cases, temperature returned to normal on discontinuation of therapy.

DINOPROSTONE (dye noe PROST one), also known as PROSTAGLANDIN E2 (pros tuh GLAN din E2) stimulates contractions of the uterus. Prostin E2®(dinoprostone vaginal suppository) is a prescription medication that causes uterine contractions. Nonetheless, the myometrial contractions induced by the vaginal administration of dinoprostone are sufficient to produce evacuation of the products of conception from the uterus in the majority of cases.Dinoprostone is also capable of stimulating the smooth muscle of the gastrointestinal tract of man.
Prostin E2 Vaginal Tablets should not be used where the patient is sensitive to prostaglandins or other constituents of the tablet.Prostin E2 Vaginal Tablets are not recommended in the following circumstances: • For patients in whom oxytocic drugs are generally contra-indicated or where prolonged contractions of the uterus are considered inappropriate such as:- Cases with a history of Caesarean section or major uterine surgery.- Cases where there is cephalopelvic disproportion.- Cases in which foetal malpresentation is present.- Cases where there is clinical suspicion or definite evidence of pre-existing foetal distress.- Cases in which there is a history of difficult labour and/or traumatic delivery.- Grand multiparae with over five previous term pregnancies. Available for Android and iOS devices. The initial rate of infusion (pump, or IV. Dinoprostone is approved for both termination of pregnancy and also for cervical ripening prior to delivery at term.

Alprostadil (brand names Caverject®, Edex®, Prostin VR®) belongs to a group of medicines called vasodilators. The following is a guide to dosage: Dilute with normal saline or 5% dextrose to produce a 1.5 micrograms/ml solution. This activity may be responsible for the vomiting and/or diarrhea that is not uncommon when dinoprostone is used to terminate pregnancy.In laboratory animals, and also in man, large doses of dinoprostone can lower blood pressure, probably as a consequence of its effect on the smooth muscle of the vascular system. STORE IN A FREEZER NOT ABOVE –20°C (–4°F) BUT BRING TO ROOM TEMPERATURE JUST PRIOR TO USE.We comply with the HONcode standard for trustworthy health information -

Each suppository contains 20 mg of dinoprostone in a mixture of glycerides of fatty acids.This product's labeling may have been updated. Because dinoprostone also causes uterine contractions, it may increase the effects of oxytocin. Dinoprostone is a prostaglandin of the E series with actions on smooth muscle; the endogenous substance is termed prostaglandin E 2. WikiDoc Resources for The list of drugs may cause diarrhea. One tablet to be inserted high into the posterior fornix. Differentiation of post-abortion endometritis from drug-induced temperature elevations is difficult, but with increasing clinical exposure and experience with PGE2 vaginal therapy the distinctions become more obviously apparent and are summarized below:In the absence of clinical or bacteriological evidence of intrauterine infection, supportive therapy for drug induced fevers includes the forcing of fluids.

When suggestions are available use up and down arrows to review and ENTER to select. In babies it is used in those with congenital heart defects until surgery can be carried out. PROSTIN E2 U.S. It works by binding and activating the prostaglandin E2 receptor. Such effects have also been noted in newborn infants who received prostaglandin EWhere the tablets are packed in a bottle, the tablets should be used within one month of opening the bottle.Amber glass bottle with screw cap and tac seal. Concomitant use with other oxytocic agents is not recommended.Carcinogenic bioassay studies have not been conducted in animals with Prostin E2 due to the limited indications for use and short duration of administration. Adults. However, these suppositories should not be given for more than 48 hours. If used in sequence, the patient's uterine activity should be carefully monitored.Prostin E2 Vaginal Tablets are only used during pregnancy, to induce labour.Prostaglandins are excreted in breast milk.

It is sometimes used after a miscarriage. As all PGE2-induced fevers have been found to be transient or self-limiting, it is doubtful if any simple empirical measures for temperature reduction are indicated.When a pregnancy diagnosed as missed abortion is electively interrupted with intravaginal administration of dinoprostone, confirmation of intrauterine fetal death should be obtained in respect to a Prostin E2 may augment the activity of other oxytocic drugs.

Overall, vaginal prostaglandin E2 compared with placebo or no treatment probably reduces the likelihood of vaginal delivery not being achieved within 24 hours.

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