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(Shown in Product Recognition Section)General Illness Information Common Name: AMENORRHEA, SECONDARY Medical Term: None specified Description: Absence of menstruation for at least 3 months in a woman who has…General Illness Information Medical Term: Parkinson’’s disease Common Name: None Specified Description: Parkinson’s disease (PD) is a chronic, progressive movement disorder which affects 1% of…General Illness Information Common Name: AMENHORRHEA, PRIMARY Medical Term: None specified Description: Complete absence of menstruation in a young woman who is at least 16…Rxmed.com ensures correct and trustworthy information about either prescription or over-the-counter drugs including natural supplements. Although there is no conclusive evidence of an interaction between bromocriptine and these drugs, their concomitant use in the puerperium is not recommended.Occupational Hazards: In some patients, dizziness (vertigo) may occur with bromocriptine; patients should therefore be cautioned against activities requiring rapid and precise responses such as driving an automobile or operating dangerous machinery until their response has been determined.Care should be exercised when administering bromocriptine concomitantly with phenothiazines or with other medications known to lower blood pressure.

In these patients, treatment with bromocriptine often results in tumor shrinkage and rapid improvement of the visual field defects.

The active parent drug and the metabolites are primarily excreted via the liver, only 6% being eliminated via the kidney.

The plasma protein binding amounts to 96%. In patients with secondary adrenal insufficiency, substitution with corticosteroids is essential. Bromocriptine may be a useful adjunct to such treatment, and can be used as monotherapy in special cases.Parkinson’s disease: Bromocriptine is effective when used as adjunct therapy to levodopa in the symptomatic management of Parkinson’s disease. If pregnancy occurs in the presence of a pituitary microadenoma, close supervision throughout pregnancy is essential. Bromocriptine inhibits the release and synthesis of prolactin by acting directly on the prolactin secreting cells of the anterior pituitary. Dosage should be adjusted accordingly.In some patients the concomitant use of bromocriptine and alcohol has given rise to alcohol intolerance and the tolerability to bromocriptine may be reduced by alcohol.In patients being treated with bromocriptine for galactorrhea, prolactin induced amenorrhea, menstrual disorders or acromegaly, infertility might be reversed by restoration of normal menses and ovulation. Causal relationship of these events to the drug is uncertain.The use of bromocriptine in the routine inhibition of physiological lactation is not recommended. This eMedTV Web page explains how the medication works and offers more information on its uses, potential side effects, and dosing guidelines.

Bromocriptine is extensively metabolized by the liver.

Bromocriptine’s metabolic pathway does not involve the formation of such peroxides and free radicals. The most common newly appearing adverse reactions in combination therapy with levodopa are: nausea, abnormal involuntary movements, hallucinations, confusion, “on-off” phenomenon, dizziness, drowsiness, faintness, fainting, vomiting, asthenia, abdominal discomfort, visual disturbance, ataxia, insomnia, depression, hypotension, shortness of breath, constipation and vertigo.General: Less common adverse reactions include: anorexia, anxiety, blepharospasm, dry mouth, dysphagia, edema of the feet and ankles, erythromelalgia, epileptiform seizures, fatigue, headache, lethargia, mottling of skin, nasal congestion, nervousness, nightmares, paresthesia, skin rash, hair loss, changes in urinary frequency, urinary incontinence and urinary retention. In cases where adverse effects, such as nausea, vomiting and vertigo are severe or persistent, the therapeutic dosage of bromocriptine should be reduced to half of 1 tablet daily (1.25 mg) and increased gradually to that recommended. Caution should be exercised when administering bromocriptine to patients with a history of myocardial infarction, particularly if they have a residual atrial, nodal or ventricular arrhythmia.Symptomatic hypotension can occur and, therefore, caution should be exercised when administering bromocriptine, particularly in patients receiving antihypertensive medication. Healthy adult male or female volunteers, 18-45 years of age.Females of childbearing potential should either be sexually inactive (abstinent) for 14 days prior to the first dose and throughout the study or be using one of the following acceptable birth control methods:Other birth control methods may be deemed acceptable.

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