sertraline vs nortriptyline

Finally, the relatively slow titration schedule of sertraline (50 mg every 3 weeks) may have served to delay its antidepressant response.

2The World Journal of Biological Psychiatry, Vol. 121 June 2013 | American Journal of Psychiatry, Vol. The significance of mean changes from baseline were determined with respect to within-group and between-group differences by using least square means from two-way analysis of covariance (ANCOVA) models with baseline values as covariates. There were 97 patients enrolled in the study (28 treated with sertraline), with an average treatment duration of 55 days. 7International Journal of Geriatric Psychiatry, Vol.

6International Journal of Geriatric Psychiatry, Vol. 2010 Feb;67(2):187-96. doi: 10.1001/archgenpsychiatry.2009.185.Rajji TK, Mulsant BH, Lotrich FE, Lokker C, Reynolds CF 3rd.Drugs Aging. 2The American Journal of Geriatric Psychiatry, Vol. 161, No.

25, No. The benefits and risks of study participation were fully explained to each patient, and written informed consent was obtained.Following a 1-week, single-blind placebo washout period, patients were randomly assigned to 12 weeks of double-blind, parallel treatment with either sertraline (in a flexible daily dose of 50–150 mg) or nortriptyline (in a flexible daily dose of 25–100 mg) provided on a three times per day schedule. 23, No. 128, No. Patients were instructed not to take study medication on visit days until after plasma samples had been obtained.

The mean sertraline doses at 6 and 12 weeks were 77 mg/day (SD=29) and 96 mg/day (SD=41), respectively. The largest F value was obtained for the last-observation-carried-forward analysis of the change in Hamilton depression scale score (F=0.99, df=1, 201, p=0.32). Alternatively, use of a fixed-dose design might have yielded results more applicable to efficacy and safety issues but less relevant to clinical practice. In assessing, for example, the effects of treatment on cognitive functioning, the POMS confusion factor and Mini-Mental State scores were examined in addition to performance on the digit symbol substitution and the shopping list tasks. In addition, for the total patient group, significant clinical benefit in favor of sertraline was noted on most secondary outcome measures, including patient self-ratings such as the POMS, assessments of cognitive performance (e.g., the digit symbol substitution and shopping list tasks), quality of life, and perceived ability to function. 15, No. 2004 Nov;58 Suppl 1(Suppl 1):25-33. doi: 10.1111/j.1365-2125.2004.01801.x. 23, No. 6The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol.

There was no interaction between treatment group and baseline severity on any of the three primary outcome measures, either by a completer or a last-observation-carried-forward analysis. 2007 Oct 16;4(4):229-246. doi: 10.1007/s10433-007-0063-3.

160, No. 25, No. Alternatively, use of a fixed-dose design might have yielded results more applicable to efficacy and safety issues but less relevant to clinical practice. In some instances (e.g., short-term memory and retrieval as measured by the recall and retrieval items on the shopping list task), 12 weeks of treatment with nortriptyline actually led to modest deterioration. 3, No. 17, No. 161, No. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. generic drugs) are not considered.

161, No.

164, No. 12The American Journal of Geriatric Psychiatry, Vol. 27, No.

7International Journal of Geriatric Psychiatry, Vol. 12, No.

Seventy-four patients treated with sertraline (70.5%) and 70 patients treated with nortriptyline (66.7%) completed the full 12 weeks of study treatment. There were notable differences on these outcomes that consistently favored sertraline treatment. 2The American Journal of Geriatric Psychiatry, Vol. 9, No. 17, No. 2000 May;157(5):729-36. doi: 10.1176/appi.ajp.157.5.729.Prog Neuropsychopharmacol Biol Psychiatry.

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