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If you are using the oral liquid, shake the bottle well … A Preclinical Meta-Analysis on Fetal Growth and Maternal Blood PressureCorrespondence to Nina D. Paauw, Division of Woman and Baby, Department of Obstetrics, University Medical Centre Utrecht, Postbus 85090, 3508 AB Utrecht, The Netherlands. This medication should not be used during pregnancy unless the benefits outweigh the risks. Of 360 planned participants, 216 pregnant women were included in the trial and 108 were randomized to sildenafil. Pregnancy category for this drug is B and pharmacokinetic data suggest 25-50 mg of Sildenafil administered orally as the initial dose for most patients. The Vermont Oxford Network.Nitric oxide-mediated vasodilation in human pregnancy.Role of nitric oxide in placental vascular development and function.Potential targets for the treatment of preeclampsia.Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia.Sildenafil citrate decreases sFlt-1 and sEng in pregnant l-NAME treated Sprague-Dawley rats.Pregnancy outcomes in patients with severe pulmonary hypertension and Eisenmenger syndrome treated with sildenafil monotherapy.Sildenafil citrate therapy for severe early-onset intrauterine growth restriction.Perinatal and hemodynamic evaluation of sildenafil citrate for preeclampsia treatment: a randomized controlled trial.A randomised, double-blinded, placebo-controlled study of the phosphodiesterase type 5 inhibitor sildenafil for the treatment of preeclampsia.STRIDER: sildenafil therapy in dismal prognosis early-onset intrauterine growth restriction–a protocol for a systematic review with individual participant data and aggregate data meta-analysis and trial sequential analysis.Systematic reviews of preclinical animal studies can make significant contributions to health care and more transparent translational medicine.Estimating the mean and variance from the median, range, and the size of a sample.Conducting meta-analyses in R with metafor package.The ratio of means method as an alternative to mean differences for analyzing continuous outcome variables in meta-analysis: a simulation study.Fixed effects and variance components estimation in three-level meta-analysis.Immune involvement in the pathogenesis of schizophrenia: a meta-analysis on postmortem brain studies.A general model for the origin of allometric scaling laws in biology.Augmented dilation to nitric oxide in uterine arteries from rats with type 2 diabetes: implications for vascular adaptations to pregnancy.Sildenafil citrate (Viagra) enhances vasodilatation in fetal growth restriction.Phosphodiesterase-5 inhibitors and omental and placental small artery function in normal pregnancy and pre-eclampsia.Sildenafil therapy for fetal cardiovascular dysfunction during hypoxic development: studies in the chick embryo.Chronic sildenafil treatment corrects endothelial dysfunction and improves hypertension.Inhibition of PDE5 restores depressed baroreflex sensitivity in renovascular hypertensive rats.Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia.Developmental toxicity of orally administered sildenafil citrate (Viagra) in SWR/J mice.Oral sildenafil citrate (viagra) for erectile dysfunction: a systematic review and meta-analysis of harms.The enigma of continual plasma volume expansion in pregnancy: critical role of the renin-angiotensin-aldosterone system.Effects of sildenafil on maternal hemodynamics and fetal growth in normal rat pregnancy.The role of arginine, homoarginine and nitric oxide in pregnancy.Sildenafil can affect innate and adaptive immune system in both experimental animals and patients.The phosphodiesterase 5 inhibitor sildenafil stimulates angiogenesis through a protein kinase G/MAPK pathway.A comparison of placental development and endocrine functions between the human and mouse model.Blood laboratory testing for early prediction of preeclampsia: chasing the finish line or at the starting blocks?Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality.Pharmacokinetics of sildenafil after intravenous and oral administration in rats: hepatic and intestinal first-pass effects.Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man.Early-onset fetal growth restriction treated with the long-acting phosphodiesterase-5 inhibitor tadalafil: a case report.Hypothesis: selective phosphodiesterase-5 inhibition improves outcome in preeclampsia.Cell-based therapies for experimental chronic kidney disease: a systematic review and meta-analysis.Placental ischemia and resultant phenotype in animal models of preeclampsia.Effects of sildenafil and tadalafil on ischemia/reperfusion injury in fetal rat brain.Sildenafil citrate increases fetal weight in a mouse model of fetal growth restriction with a normal vascular phenotype.The effects of sildenafil citrate on feto-placental development and haemodynamics in a rabbit model of intrauterine growth restriction [published online ahead of print May 23, 2016].Effect of sildenafil on pre-eclampsia-like mouse model induced by L-NAME.Effects of sildenafil in Nω-nitro-L-arginine methyl ester-induced intrauterine growth restriction in a rat model.Maternal administration of sildenafil citrate alters fetal and placental growth and fetal- placental vascular resistance in the growth- restricted ovine fetus.Sildenafil citrate and fetal outcome in pregnant rats.Effects of sildenafil on the fetal growth of guinea pigs and their ability to survive induced intrapartum asphyxia.Sildenafil citrate treatment enhances amino acid availability in the conceptus and fetal growth in an ovine model of intrauterine growth restriction.Sildenafil attenuates placental ischemia-induced hypertension.Sildenafil treatment ameliorates the maternal syndrome of preeclampsia and rescues fetal growth in the dahl salt-sensitive rat.Sildenafil citrate improves perinatal outcome in fetuses from pre-eclamptic rats.Haemodynamic effects of long-term administration of sildenafil in normotensive pregnant and non-pregnant rats.Sildenafil citrate improves fetal outcomes in pregnant, L-NAME treated, Sprague-Dawley rats.Sildenafil treatment in a nonsevere hypertensive murine model lowers blood pressure without reducing fetal growth.Sildenafil citrate rescues fetal growth in the catechol-O-methyl transferase knockout mouse model.The effect of sildenafil on the altered thoracic aorta smooth muscle responses in rat pre-eclampsia model.Treatment with sildenafil prevents impairment of learning in rats born to pre-eclamptic mothers.

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