simvastatin interactions grapefruit lotrisone

The drugs that can interact with this citrus fruit includes statins. This may increase your risk of developing serious muscle disorders.While you are taking this medicine, do not eat grapefruit or drink grapefruit juice at any time. It’s rich in antioxidants, vitamins, and fiber.A slower breakdown of a drug means you’ll have more of that drug in your bloodstream. Just one grapefruit or one glass of grapefruit juice Keep in mind that both fresh and frozen juices have the same effect.If you accidentally consume a small amount of grapefruit, it isn’t likely to affect your medication. More of the drug in your bloodstream can cause certain side effects and affect how well the drug works.So, which medications should you avoid mixing with grapefruit and grapefruit juice? Sometimes, grapefruit interacts with only some of the drugs in a category, not all.For example, you might need to stop taking lovastatin, atorvastatin, or simvastatin, but you might be able to take fluvastatin, pitavastatin, pravastatin, or rosuvastatin to lower your cholesterol.If you have doubts or questions, talk to your doctor about the risks of mixing medications and grapefruit.If I have a grapefruit or glass of grapefruit juice, is there a safe amount of time I should wait before taking my medication or vice versa?The effect of grapefruit juice on some drugs may last longer than 24 hours and avoiding drinking any grapefruit juice is wise advice.

You only need to avoid grapefruit if your doctor prescribes lovastatin, atorvastatin, or simvastatin.The secret to the interaction between grapefruit and these statins is in furanocoumarins, according to a This compound deactivates the CYP3A4 enzyme that the body uses to metabolize, or process, these particular statins. This information is generalized and not intended as specific medical advice. Do not start, stop, or change your medicine or diet before checking with them first.Selected from data included with permission and copyrighted by First Databank, Inc. These include many drugs used to treat blood vessel and heart conditions.Grapefruit also interacts with drugs used to treat nausea and urinary tract infections, anti-rejection drugs, medications to treat cancer, and many drugs that affect the central nervous system, including anti-anxiety drugs.Similar to how it affects certain statins, furanocoumarins in grapefruit can suppress the enzyme that helps your body process these medications. In the event that you are instructed by a healthcare professional (e.g., doctor, pharmacist, or dietitian) to eat grapefruit or drink grapefruit juice, you should immediately discuss with your doctor the effects of grapefruit on the blood levels of this medicine. If you use a skin patch or receive your medication through an injection, you may have a lower risk of adverse effects.There’s the risk of increased side effects when mixing grapefruit with lovastatin, atorvastatin, or simvastatin.

The list includes tangelos, pomelos, bitter oranges, and Seville oranges. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment.Very important. For this reason, you might avoid the fruit altogether. Some people can lower their cholesterol with lifestyle changes. While you are taking this medicine, do not eat grapefruit or drink grapefruit juice at any time. The exact amount of grapefruit it takes to have a negative reaction when taking lovastatin, atorvastatin, or simvastatin is unknown.

You may choose an alternative citrus beverage (such as orange juice).
Q: I've heard that people shouldn't drink grapefruit juice if they're taking a statin. Grapefruit juice increases the level of simvastatin in your blood and makes side effects more likely.

Why? Our website services, content, and products are for informational purposes only. If you’re prescribed a statin, it’s important to understand which ones can interact negatively with grapefruit and grapefruit juice. You may choose an alternative citrus beverage (such as orange juice). This doesn’t mean that you have to avoid grapefruit altogether if you’re prescribed this medication.The fruit doesn’t affect all statins.
A: Certain classes of drugs — most notably statins — are metabolized (broken down) in your intestines by an enzyme called CYP3A, which normally reduces the amount of drug that enters your bloodstream.Grapefruit juice contains compounds called furanocoumarins that stop CYP3A from doing its job. Contact your healthcare professional (e.g., doctor or pharmacist) for more information.Your healthcare professionals may be aware of this interaction and may be monitoring you for it.

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