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In addition, the Scale for Assessing Negative Symptoms (SANS) was employed for assessing negative symptoms in one trial.The efficacy of ziprasidone was established in 2 placebo-controlled, double-blind, 3-week monotherapy studies in patients meeting The results of the oral ziprasidone trials in adult bipolar I disorder, manic/mixed episode follow: in a 3-week placebo-controlled trial (n=210), the dose of ziprasidone was 40 mg twice daily on Day 1 and 80 mg twice daily on Day 2. Less than one-third of ziprasidone metabolic clearance is mediated by cytochrome P450 catalyzed oxidation.Ziprasidone should not be used with any drug that prolongs the QT interval [see Given the primary CNS effects of ziprasidone, caution should be used when it is taken in combination with other centrally acting drugs.Because of its potential for inducing hypotension, ziprasidone may enhance the effects of certain Ziprasidone may antagonize the effects of levodopa and Carbamazepine is an inducer of CYP3A4; administration of 200 mg twice daily for 21 days resulted in a decrease of approximately 35% in the AUC of ziprasidone. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Dystonic symptoms include: spasm of the neck muscles, sometimes progressing to tightness of the throat, swallowing difficulty, difficulty breathing, and/or protrusion of the tongue.

Any unused portion should be discarded. In the flexible-dose clinical trials, the mean daily dose administered was approximately 120 mg [see Continue treatment at the same dose on which the patient was initially stabilized, within the range of 40 mg-80 mg twice daily with food. A second widely used assessment, the Clinical Global Impression (CGI), reflects the impression of a skilled observer, fully familiar with the manifestations of schizophrenia, about the overall clinical state of the patient. Treatment typically involves talk therapy and medication.Brief psychotic disorder is a short-term mental illness that features psychotic symptoms. There are no known clinically relevant inhibitors or inducers of aldehyde oxidase. Advise patients that GEODON may cause extrapyramidal and/or Advise breastfeeding women using GEODON to monitor infants for excess sedation, irritability, poor feeding, and extrapyramidal symptoms (tremors, and abnormal muscle movements) and to seek medical care if they notice these signs [see Advise females of reproductive potential that GEODON may impair fertility due to an increase in serum prolactin levels. The injectable form is available in vials containing 20 mg of lyophilized ziprasidone that must be reconstituted with 1.2 ml of sterile water before injection.Capsules should be stored at room temperature, from 15 C to 30 C (59 F Exposure increases in a dose-related manner and following three days of intramuscular dosing, little accumulation is observed.Although the metabolism and elimination of IM ziprasidone have not been systematically evaluated, the intramuscular route of administration would not be expected to alter the metabolic pathways.The efficacy of oral ziprasidone in the treatment of schizophrenia was evaluated in 5 placebo-controlled studies, 4 short-term (4-and 6-week) trials and one maintenance trial. The multiple-dose pharmacokinetics of ziprasidone are dose-proportional within the proposed clinical dose range, and ziprasidone accumulation is predictable with multiple dosing. Before you start GEODON, be sure to tell your doctor if you:Your doctor may want you to get additional laboratory tests to see if GEODON is an appropriate treatment for you.There are some medications that may be unsafe to use when taking GEODON, and there are some medicines that can affect how well GEODON works.

Tell your doctor about all your medications and any you start or stop using during treatment with Geodon. Other severe cutaneous adverse reactions (SCAR), such as Stevens-Johnson syndrome can occur with ziprasidone. Doses of 10 mg may be administered every two hours; doses of 20 mg may be administered every four hours up to a maximum of 40 mg/day. Efficacy was evaluated by analysis of the area under the curve (AUC) of the Behavioural Activity Rating Scale (BARS) and Clinical Global Impression (CGI) severity rating. GEODON Capsules are supplied for oral administration in 20 mg (blue/white), 40 mg (blue/blue), 60 mg (white/white), and 80 mg (blue/white) capsules. The patient should be carefully monitored, since recurrences of NMS have been reported.Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) has been reported with Ziprasidone exposure.

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