stopping alendronate after 5 years manforce

J.R.M.

Wolters Kluwer Health Patients who required vitamin D supplementation, according to the investigator's medical judgment, received vitamin D supplements (up to 500 IU/d) throughout the trial.Before enrollment, the change in bone mass over the preceding 7-yr period was reviewed. Folder Name:

R.E.

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Richard Eastell, Rosemary A. Hannon, Dietrich Wenderoth, Jesus Rodriguez-Moreno, Andrzej Sawicki, Effect of Stopping Risedronate after Long-Term Treatment on Bone Turnover, Determining how quickly bisphosphonate treatment effects begin to regress is crucial when considering termination of treatment.Our objective was to assess the effects of 1 yr discontinuation of risedronate use in postmenopausal women with osteoporosis who had previously received risedronate for 2 or 7 yr.Before initiation of the current study, placebo/5-mg-risedronate patients had received placebo for 5 yr and risedronate for 2 yr, whereas 5-mg-risedronate patients had received risedronate for a total of 7 yr. Risedronate was then discontinued for 1 yr (yr 8).Postmenopausal women with osteoporosis who had previously completed the 3-yr Vertebral Efficacy with Risedronate Therapy MultiNational (VERT-MN) pivotal trial, plus a 2-yr extension comparing risedronate or placebo for a total of 5 yr, followed by 2 yr of open-label risedronate treatment were enrolled in these trial extensions.Evaluations included changes in type I collagen cross-linked N-telopeptide (NTX)/creatinine (Cr) and bone mineral density (BMD) values, fracture incidence, and adverse events.After 1 yr of risedronate discontinuation, NTX/Cr levels increased toward baseline in both patient groups One year of discontinuation of risedronate treatment in patients who had received 2 or 7 yr of risedronate therapy led to increases in NTX/Cr levels toward baseline and decreases in femoral trochanter and total hip BMD.Although bisphosphonate therapy has proven efficacious in the treatment of osteoporosis, the optimal duration of treatment is still unknown.

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800-638-3030 remodeling compared with discontinuation after 5 years. Effects of Continuing or Stopping Alendronate After 5 Years of Treatment The Fracture Intervention Trial Long-term Exte nsion (FLEX): A Randomized Trial Dennis M. Black, PhD San Francisco Coordinating Center; Departments of Epidemiology and Biostatistics and Medicine, University of California, San Francisco, and California Pacific Medical Research Institute, San Francisco; Department of Medicine, VA Medical Center, Minneapolis, Minnesota; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Medicine, University of Miami, Miami, Florida; School of Medicine, Wake Forest University, Winston-Salem, North Carolina; Department of Preventive Medicine, University of Tennessee, Memphis; College of Medicine, University of Iowa, Iowa city; and Merck Research Laboratories, Rahway, New JerseyPharmacokinetic studies have shown that bisphosphonates remain in the bone matrix for many years and are gradually released as bone is resorbed. Bl, Baseline; RIS, risedronate.Mean percent change of the total hip (A) and femoral trochanter (B) BMD from pivotal study baseline to the end of yr 8. This website uses cookies.

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