sulfasalazine side effects rash erythromycin

Siam AR, Hammoudeh M "Sulfasalazine induced systemic lupus erythematosus in a patient with rheumatoid arthritis." Gastroenterology 75 (1978): 95-942. Chest 101 (1992): 1033-769. Jick H, Myers MW, Dean AD "The risk of sulfasalazine- and mesalazine-associated blood disorders." Dery CL, Schwinghammer TL "Agranulocytosis associated with sulfasalazine."

J Pediatr 92 (1978): 450-12. Am J Gastroenterol 88 (1993): 1416-2021. J Rheumatol 18 (1991): 634-54. J Rheumatol 20 (1993): 909-1053. J Rheumatol 19 (1992): 621-249. Int Surg 70 (1985): 271-29. Drug Intell Clin Pharm 22 (1988): 139-4243. Ann Pharmacother 27 (1993): 1052-444. Poland GA, Love KR "Marked atypical lymphocytosis, hepatitis, and skin rash in sulfasalazine drug allergy." If experienced, these tend to have a Less Severe expressionIf experienced, these tend to have a Severe expressionIf experienced, these tend to have a Severe expressionIf experienced, these tend to have a Less Severe expressionSelected from data included with permission and copyrighted by First Databank, Inc. Postgrad Med 79 (1986): 193-4,31. These side effects usually happen during the first three months of treatment and often clear up if the dose is lowered. Ann Intern Med 101 (1984): 377-868. Abnormal Urine Color 2. Although not all of these side effects may occur, if they do occur they may need medical attention.Some side effects of sulfasalazine may occur that usually Check with your health care professional if any of the following side effects The most common side effects reported were anorexia, headache, nausea, vomiting, gastric distress, elevated temperature, The use of enteric-coated preparations may decrease gastrointestinal side effects.Diuresis has been reported rarely in patients using Infertility appeared to be reversible upon drug discontinuation.Angioedema was reported during postmarketing experience with the use of products containing or metabolized to The risk of Stevens-Johnson syndrome or toxic epidermal necrolysis increased largely with the use of sulfonamides; however, these phenomena were rare as a whole.Immunoglobulin suppression was slowly reversible and rarely accompanied by clinical findings.In most cases of sulfasalazine-induced SLE, patients received the drug for greater than 1 year. Haines JD, Jr "Hepatotoxicity after treatment with sulfasalazine." Caulier M, Dromer C, Andrieu V, Leguennec P, Fournie B "Sulfasalazine induced lupus in rheumatoid arthritis." Ring FA, Hershfield NB, Machin GA, Scott RB "Sulfasalazine-induced colitis complicating idiopathic ulcerative colitis."

Kuipers EJ, Vellenga E, de Wolf JT, Hazenberg BP "Sulfasalazine induced agranulocytosis treated with GM-CSF." Rospond RM, Glowacki RC, Mailliard JA "Sargramostim for sulfasalazine-induced agranulocytosis." Rubin R "Sulfasalazine-induced fulminant hepatic failure and necrotizing pancreatitis." Erturk E, Casemento JB, Guertin KR, Kende AS "Bilateral acetylsulfapyridine nephrolithiasis associated with chronic sulfasalazine therapy." Am J Gastroenterol 76 (1981): 374-615.

Leroux JL, Ghezail M, Chertok P, Blotman F "Hypersensitivity reactions to sulfasalazine: skin rash, fever, hepatitis and activated lymphocytes." Roujeau JC, Kelly JP, Naldi L, et al. Guillemin F, Aussedat R, Guerci A, Lederlin P, Trechot P, Pourel J "Fatal agranulocytosis in sulfasalazine treated rheumatoid arthritis." Respiratory changes generally resolved over a few weeks, however, fatal reactions involving fibrosing alveolitis have been reported.The following side effects have been reported as hypersensitivity reactions: erythema multiforme (Stevens-Johnson syndrome), exfoliative dermatitis, epidermal necrolysis (Lyell's syndrome) with corneal damage, drug rash with eosinophilia and systemic symptoms (DRESS), anaphylaxis, serum sickness syndrome, pneumonitis (with or without eosinophilia), vasculitis, fibrosing alveolitis, pleuritis, pericarditis (with or without tamponade), allergic myocarditis, polyarteritis nodosa, lupus erythematosus-like syndrome, hepatitis and hepatic necrosis (with or without immune complexes), fulminant hepatitis (sometimes leading to liver transplantation), parapsoriasis varioliformis acuta (Mucha-Haberman syndrome), rhabdomyolysis, photosensitization, arthralgia, periorbital edema, conjunctival and scleral injection, alopecia, and interstitial lung disease.Anaphylaxis was reported during postmarketing experience with the use of products containing or metabolized to mesalamine.At least 1 patient developed bilateral renal calculi composed of acetylsulfapyridine, a metabolite of sulfasalazine.Goiter production has been reported rarely in patients using sulfonamides.1. You may be able to increase the dose again after a while if your reaction to sulfasalazine improves and it’s helping your symptoms. Am J Gastroenterol 79 (1984): 7767.

Associated rash usually progressed to desquamation.

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