tenofovir + lamivudine brand name wellbutrin

In controlled trials of 1,008 patients treated with regimens containing EFV for a mean of 2.1 years and 635 patients treated with control regimens for a mean of 1.5 years, the frequency (regardless of causality) of specific serious psychiatric events among patients who received EFV or control regimens, respectively, were severe depression (2.4%, 0.9%), suicidal ideation (0.7%, 0.3%), nonfatal suicide attempts (0.5%, 0), aggressive behavior (0.4%, 0.5%), paranoid reactions (0.4%, 0.3%), and manic reactions (0.2%, 0.3%). Each tablet contains 400 mg of efavirenz, 300 mg of lamivudine and 300 mg of tenofovir disoproxil fumarate, which is equivalent to 245 mg of tenofovir … The effects of coadministration of EFV on the Cmax, AUC, and Cmin are summarized in Table 8 (effect of EFV on other drugs) and Table 9 (effect of other drugs on EFV). The incidence of Grade 4 rash (e.g., erythema multiforme, Stevens- Johnson syndrome) in patients treated with EFV in all studies and expanded access was 0.1%. Side effects may include trouble sleeping and weight gain. In a study using EFV 600 mg, onset of new serious psychiatric symptoms occurred throughout the study for both EFV-treated and control-treated patients. In the United States, it was approved by the Food and Drug Administration (FDA) in February 2018, for the treatment of HIV-1 infection. Mild adverse reactions (Grade 1) were common with a similar incidence in both arms and included dizziness, diarrhea, and nausea. Available data from the APR show no difference in the risk of major birth defects for EFV and 3TC compared to the background rate for major birth defects of 2.7% in the U.S. reference population of the Metropolitan Atlanta Congenital Defects Program (MACDP). These reactions have been chosen for inclusion due to a combination of their seriousness, frequency of reporting, or potential causal connection to EFV, 3TC, and TDF.The following adverse reactions, listed under the body system headings above, may occur as a consequence of proximal renal tubulopathy: rhabdomyolysis, osteomalacia, hypokalemia, muscular weakness, myopathy, hypophosphatemia.Efavirenz, Lamivudine and Tenofovir disoproxil fumarate is a complete regimen for the treatment of HIV-1 infection; therefore, it should not be administered with other antiretroviral medications for treatment of HIV-1 infection.There is limited information available on the potential for a pharmacodynamic interaction between EFV and drugs that prolong the QTc interval. 1 tablet (lamivudine 300 mg/tenofovir 300 mg) PO qDay in combination with other ARTs. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. A causal relationship has not been established.QTc prolongation has been observed with the use of EFV The following adverse reactions are discussed in other sections of the labeling:Because clinical studies are conducted under widely varying conditions, the adverse reaction rates observed in clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.In Trial 903, 600 antiretroviral-naïve subjects received TDF (N = 299) or stavudine (d4T) (N = 301) administered in combination with 3TC and EFV for 144 weeks. Careful monitoring is recommended for patients with mild hepatic impairment receiving EFV Monitoring of liver enzymes before and during treatment is recommended for all patients Discontinue Efavirenz, Lamivudine and Tenofovir disoproxil fumarate if elevation of serum transaminases is accompanied by clinical signs or symptoms of hepatitis or hepatic decompensation.In pediatric patients with a history of prior antiretroviral nucleoside exposure, a history of pancreatitis, or other significant risk factors for the development of pancreatitis, 3TC, a component of Efavirenz, Lamivudine and Tenofovir disoproxil fumarate tablets, should be used with caution. False-positive urine cannabinoid test results have been reported with some screening assays in uninfected and HIV-infected subjects receiving EFV. If it is near the time of the next dose, skip the missed dose. Take Symfi on an empty stomach and preferably at bedtime. QT prolongation can cause irregular heartbeats that can be life-threatening.Call your doctor for medical advice about side effects. There were no new safety findings in pregnant women compared with the known safety profile of tenofovir disoproxil fumarate in HBV-infected adults. It is soluble in methanol and practically insoluble in water (< 10 microgram/mL).Lamivudine USP is a white or almost white powder and is soluble in water.The chemical name of tenofovir disoproxil fumarateis 9-[(Tenofovir disoproxil fumarate is a white to off white powder freely soluble in dimethyl formamide, soluble in methanol and slightly soluble in water at 25°C.

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