tolterodine prescribing information paroxetine

Study subjects [approximately equal representation of CYP2D6 extensive metabolizers (EMs) and poor metabolizers (PMs)] completed sequential 4-day periods of dosing with moxifloxacin 400 mg QD, tolterodine 2 mg BID, tolterodine 4 mg BID, and placebo. There may be circumstances when it is necessary to initiate treatment with an MAOI such as linezolid or intravenous methylene blue in a patient taking clomipramine. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are.Call your doctor for medical advice about side effects. The maximum licensed dose for the treatment of generalized anxiety disorder (GAD) is 50 mg/day. Nevertheless, caution is necessary in treating patients with known cardiovascular disease, and gradual dose titration is recommended.Patients treated with clomipramine have been reported to show a variety of neuropsychiatric signs and symptoms including delusions, hallucinations, psychotic episodes, confusion, and paranoia. Administer tolterodine tartrate extended-release capsules with caution in patients with gastrointestinal obstructive disorders because of the risk of gastric retention.Tolterodine tartrate extended-release capsules, like other antimuscarinic drugs, may decrease gastrointestinal motility and should be used with caution in patients with conditions associated with decreased gastrointestinal motility (e.g.

If you experience these symptoms, you should stop taking tolterodine tartrate extended-release capsules and get emergency medical help right away.The most common side effects with tolterodine tartrate extended-release capsules are:Medicines like tolterodine tartrate extended-release capsules can cause blurred vision, dizziness, and drowsiness.Do not drive, operate machinery or do other dangerous activities until you know how tolterodine tartrate extended-release capsules affect you.Call your doctor for medical advice about side effects. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Select one or more newsletters to continue.

It may harm them.This leaflet summarizes the most important information about Tolterodine Tartrate Tablets.

Paroxetine: (Moderate) Paroxetine, a potent CYP2D6 inhibitor, may inhibit the metabolism of tolterodine, a CYP2D6 substrate. A list of drugs that interact with Paroxetine. Both tolterodine and the 5-hydroxymethyl metabolite exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels.Tolterodine has a pronounced effect on bladder function. Pregnant rabbits administered tolterodine subcutaneously at about 0.3-2.5 times the clinical exposure (dose of 0.8 mg/kg/day) did not show any embryotoxicity or teratogenicity.There is no information on the presence of tolterodine or its 5-HMT metabolite in human milk, the effects on the breastfed infant, or the effects on milk production. However, no overall differences were observed in safety between older and younger patients on tolterodine in the Phase 3, 12-week, controlled clinical studies; therefore, no tolterodine dosage adjustment for elderly patients is recommended.Renal impairment can significantly alter the disposition of tolterodine immediate release and its metabolites. Exposure levels of other metabolites of tolterodine (e.g., tolterodine acid, Liver impairment can significantly alter the disposition of tolterodine immediate release. Prescribing and dispensing information The need for continuing therapy for urinary incontinence should be reviewed every 4–6 weeks until symptoms stabilise, and then every 6–12 months. These data were obtained following single and multiple doses of tolterodine 4 mg administered twice daily to 16 healthy male volunteers (8 EM, 8 PM).Table 2 summarizes the mean change from baseline to steady state in corrected QT interval (QTc) relative to placebo at the time of peak tolterodine (1 hour) and moxifloxacin (2 hour) concentrations. The complete text of the Medication Guide is reprinted at the end of this document.Patients should be advised of the following issues and asked to alert their prescriber if these occur while taking clomipramine hydrochloride.Patients, their families, and their caregivers should be encouraged to be alert to the emergence of anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia (psychomotor restlessness), hypomania, mania, other unusual changes in behavior, worsening of depression, and suicidal ideation, especially early during antidepressant treatment and when the dose is adjusted up or down. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Caution is indicated in treating patients with known liver disease, and periodic monitoring of hepatic enzyme levels is recommended in such patients.Although no instances of severe hematologic toxicity were seen in the premarketing experience with clomipramine, there have been postmarketing reports of leukopenia, agranulocytosis, thrombocytopenia, anemia, and pancytopenia in association with clomipramine hydrochloride capsules USP use.

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