tolterodine tartrate 2mg duricef

Administer tolterodine tartrate extended-release capsules with caution in patients with gastrointestinal obstructive disorders because of the risk of gastric retention.Tolterodine tartrate extended-release capsules, like other antimuscarinic drugs, may decrease gastrointestinal motility and should be used with caution in patients with conditions associated with decreased gastrointestinal motility (e.g. The effect of prokinetics like metoclopramide and cisapride may be decreased by tolterodine. Your doctor may use a lower dose of tolterodine tartrate extended-release capsules if you are taking:Know the medicines you take. The absolute bioavailability of tolterodine is 17 % in extensive metabolisers, the majority of the patients, and 65% in poor metabolisers (devoid of CYP2D6). Pharmakologischgenutzt wird der aromatischeKohlenwasserstoffin der Regel in Form von Tolterodintartat mit der Summenformel: C22H31NO • C4H6O6 Bei Zimmertemperaturliegt die Substanz als weißer, pulverartiger Feststoff vor. Frankreich. ketoconazole and itraconazole) and antiproteases is not recommended due to increased serum concentrations of tolterodine in poor CYP2D6 metabolisers with (subsequent) risk of overdosage (see section 4.4). A subset (about 7%) of the population is devoid of CYP2D6 activity. The empirical formula of tolterodine tartrate is C 26 H 37 … It allows continued monitoring of the benefit/risk balance of the medicinal product. In a study of tolterodine immediate release conducted in cirrhotic patients (Child-Pugh Class A and B), the elimination half-life of tolterodine immediate release was longer in cirrhotic patients (mean, 7.8 hours) than in healthy, young, and elderly volunteers (mean, 2 to 4 hours). The chemical name of tolterodine tartrate is (R)-N,N-diisopropyl-3-(2-hydroxy-5methylphenyl)-3-phenylpropanamine L-hydrogen tartrate. The safety, tolerability and clinical response are similar irrespective of phenotype. Impaired renal function: The mean exposure of unbound tolterodine and its 5-hydroxymethyl metabolite is doubled in patients with severe renal impairment (inulin clearance GFR ≤30 ml/min). The study could not provide convincing evidence that tolterodine had effects over placebo in patients with sensory urgency. Therefore an increase of plasma levels of drugs metabolised by these isoenzymes is not expected when dosed in combination with tolterodine.There are no adequate data from the use of tolterodine in pregnant women. A serious adverse event was reported by 1.4% (n=7) of patients receiving tolterodine tartrate extended-release capsules and by 3.6% (n=18) of patients receiving placebo.Table 1 lists the adverse events, regardless of causality, that were reported in the randomized, double-blind, placebo-controlled 12-week study at an incidence greater than placebo and in greater than or equal to 1% of patients treated with tolterodine tartrate extended-release capsules 4 mg once daily.% Tolterodine tartrate extended release capsules n=505The frequency of discontinuation due to adverse events was highest during the first 4 weeks of treatment. A total of 710 paediatric patients (486 on tolterodine and 224 on placebo) aged 5-10 years with urinary frequency and urge urinary incontinence were studied. Conversely, the therapeutic effect of tolterodine may be reduced by concomitant administration of muscarinic cholinergic receptor agonists. Efficacy of Tolterodine Tartrate has not been demonstrated in children (see section 5.1). The effect of tolterodine 8 mg/day was not as large as that observed after four days of therapeutic dosing with the active control moxifloxacin. Tolterodine should be avoided during lactation.Animal studies do not show an effect of tolterodine on fertility (see section 5.3). Tolterodine Tartrate 1 mg/2 mg Film-coated Tablet. After oral administration tolterodine is subject to CYP2D6 catalysed first-pass metabolism in the liver, resulting in the formation of the 5-hydroxymethyl derivative, a major pharmacologically equipotent metabolite. Because of the differences in the protein-binding characteristics of tolterodine and the 5-hydroxymethyl metabolite, the exposure (AUC) of unbound tolterodine in poor metabolisers is similar to the combined exposure of unbound tolterodine and the 5-hydroxymethyl metabolite in patients with CYP2D6 activity given the same dosage regimen.

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