trazodone dog forum clonidine

… Clonidine has a wide dosing range (0.01 to 0.05 mg/kg). The results suggest that PRN use of clonidine may be useful in addition to being well tolerated for the treatment of fear … Behavioral medications may be used to augment behavioral treatments for fear-based problems in dogs, particularly when the signs are severe or the feared stimulus is impossible to control. It is available in 0.1-, 0.2-, and 0.3-mg tablets. In group A, the primary diagnoses were separation anxiety, noise phobia, storm phobia, or a combination of these conditions. Exercise caution when using clonidine in patients with existing cardiac disease.3 Starting at the lower end of the dose range and gradually tapering upward can help minimize the severity of side effects.

Without the appropriate and judicious use of these medications, many dogs would be much less likely to respond to behavior modification therapy. Trazodone can also be used as a single agent.

Regular daily dosing is more common with generalized anxiety disorders in which it is difficult to identify a specific trigger, and as-needed dosing is used when those stimuli can be predictably recognized. (An example of another alpha-2 agonist used in veterinary medicine is the injectable sedative dexmedetomidine.)

When combined with an SSRI or a TCA, trazodone may increase the risk of seizures due to an unknown etiology, but consider that it could be a consequence of serotonin syndrome (Most side effects diminish with time, so often waiting is the best response to the appearance of mild to moderate side effects. It is metabolized by the hepatic cytochrome P450 system and reaches its peak plasma concentration at 445 ± 271 minutes; its half-life is 169 ± 53 minutes after a single oral dose.5 Trazodone can be administered as needed, daily as often as every eight hours, or by using a combination of the two schedules. (An example of another alpha-2 agonist used in veterinary medicine is the … In group B, the primary diagnoses were fear aggression or a combination of fear and fear-based territorial aggression. If the first two steps prove ineffective in managing the case, combination drug therapy is a viable alternative. In this article, we review the use of clonidine and trazodone in dogs, two medications that are being used more frequently in behavior specialty practices to manage a variety of anxiety-based behavior problems. Clonidine is metabolized by the liver and excreted by the kidneys, so exercise caution in patients with compromised hepatic or renal function. It is usually dosed on an as-needed basis but can be given up to every eight hours. The increase in alpha-2 adrenoreceptor functioning results in a decrease in norepinephrine release from the locus ceruleus. Compounds with longer half-lives, such as SSRIs, can be discontinued abruptly, if necessary. Clonidine is classified primarily as an alpha-2 agonist. In group A, the clinical outcome was compared with previous pharmacologic treatments according to owner assessments. In some cases, however, use of a single pharmaceutical agent does not provide sufficient anti-anxiety effects to achieve a suitable outcome. Through its activation of the hypothalamic-pituitary-adrenal axis, norepinephrine is associated with fear-based responses … It is recommended to begin dosing at 2 to 3 mg/kg orally every 24 hours and then gradually taper up to effect. Of the 12 owners (92%) in group B, 11 reported that clonidine reduced the intensity of aggressive response of the dogs during the drug’s active phase. Dosing at the lower end of the range should be sufficient when trazodone is used along with a primary agent such as a TCA or an SSRI.

In some cases, however, these effects can be more prolonged and serious.

It has a short half-life (7.7 hours in people2), with its effect reducing over four to six hours. Therefore, trazodone is used in situations in which there is an identifiable stimulus, such as thunderstorms, or before an owner's departure in separation anxiety cases.6 Trazodone is dosed at 1.7 to 9.5 mg/kg orally every eight to 24 hours. Clonidine is commonly used to treat noise phobias (including thunderstorms and generalized noise responses), separation anxiety, and fear-based aggression with identifiable triggers. In both groups, the most effective PRN dose of clonidine and any adverse effects were noted. According to global assessment by owners, 7 of the 10 owners (70%) in group A reported that clonidine was more effective as compared with the previously given medications. In veterinary behavior medicine, clonidine is most often used as an add-on agent, combined with an SSRI such as fluoxetine or a TCA such as clomipramine. Side effects commonly include gastrointestinal effects (vomiting and diarrhea), sedation, ataxia, hypotension, excitement or agitation, and panting.

Trazodone For Dogs Dosage. ScienceDirect ® is a registered trademark of Elsevier B.V.The use of clonidine in the treatment of fear-based behavior problems in dogs: An open trialThis study was presented at the annual meeting of American College of Veterinary Behaviorists and American Veterinary Society of Animal Behavior Symposium, July 30th 2010, Atlanta, GA.Copyright © 2011 Elsevier Inc. All rights reserved.ScienceDirect ® is a registered trademark of Elsevier B.V.

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