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This product could help youAccessing resources off campus can be a challenge. Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website.Osteoarthritis: an update with relevance for clinical practiceThe effect of osteoarthritis definition on prevalence and incidence estimates: a systematic reviewComparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysisOARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelinesCommentary on recent therapeutic guidelines for osteoarthritisUse of non-steroidal anti-inflammatory drugs that elevate cardiovascular risk: an examination of sales and essential medicines lists in low-, middle-, and high-income countriesAssociation between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation: an overview of epidemiologic studies published in the 1990sGastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugsEvidence of aspirin use in both upper and lower gastrointestinal perforationConsumption of non-steroidal anti-inflammatory drugs and the development of functional renal impairment in elderly subjects. The proportion of patients with an upper gastrointestinal event was higher with ibuprofen than with celecoxib. Celecoxib capsules were administered orally as 200 mg capsules. References: Given the low number of events in this study, the lack of a significant difference between active treatment groups is not surprising. The PPA population was the subset of the MITT population who had no major protocol violations and completed all four visits, including at baseline.The study was conducted in compliance with the ethical principles originating in, or derived from, the Declaration of Helsinki and in compliance with the Independent Review Boards at each participating centre, informed consent regulations and International Congress of Harmonisation Good Clinical Practice Guidelines. Manuscript content on this site is licensed under Creative Commons Licenses. Ibuprofen 800 mg tablets were administered orally. The Mayo Clinic reports that the oral Celebrex capsule works only on COX-2 inhibitors to block the chemicals producing pain and inflammation in disease conditions 4. Conclusions: Celecoxib has a more favorable overall safety profile than naproxen or ibuprofen when taken without aspirin. The difference between celecoxib and placebo was significant (At week 6, a greater proportion of patients in the celecoxib (51.7%, 78 of 151) and ibuprofen (46.4%, 70 of 151) groups had their arthritis condition rated as ‘good’ or ‘very good’ compared with the placebo group (35.9%, 28 of 78) (There were significant improvements in total WOMAC OA score and individual domain scores in the celecoxib and ibuprofen groups compared with placebo (A greater proportion of patients in the celecoxib and ibuprofen groups than in the placebo group agreed with the Pain Satisfaction Scale questions (A total of 100 patients reported 136 treatment-emergent AEs (Upper gastrointestinal events (sum of moderate or severe abdominal pain, dyspepsia and/or nausea) were reported less frequently with celecoxib (1.3%, 2 of 153) than in the ibuprofen (5.1%, 8 of 156) or placebo (2.5%, 2 of 79) groups, although these differences were not significant (In this 6-week non-inferiority study, celecoxib (at 200 mg/day) was as effective as high-dose ibuprofen (2400 mg/day) for the treatment of pain associated with OA. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice.

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