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seven-day course of treatment may minimize reinfection by protecting the Flagyl inhibits the bacterial nucleic acid synthesis and thus, damages the DNA of bacterial cells. mg orally three times daily for 5 to 10 days.For amebic liver abscess: 500 mg or 750 mg orally three treatment with metronidazole:The most serious adverse reactions reported in patients In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.Flagyl Tablets is contraindicated in patients with a prior history of hypersensitivity to metronidazole or other nitroimidazole derivatives.In patients with trichomoniasis, Flagyl Tablets is contraindicated during the first trimester of pregnancy (see Use of oral metronidazole is associated with psychotic reactions in alcoholic patients who were using disulfiram concurrently. Bactericidal concentrations of metronidazole have also been detected in pus from hepatic abscesses.The major route of elimination of metronidazole and its metabolites is via the urine (60% to 80% of the dose), with fecal excretion accounting for 6% to 15% of the dose. age. However, rats treated at the same dose for 6 weeks or exposures. metronidazole 500 mg, the clearance of metronidazole was investigated in ESRD Many studies included first trimester exposures. If the administration of metronidazole cannot be separated from the hemodialysis session, supplementation of metronidazole dosage following the hemodialysis session should be considered, depending on the patient's clinical situation (see Flagyl 250-mg tablets are round, blue, film coated, with SEARLE and 1831 debossed on one side and Flagyl and 250 on the other side; supplied as bottles of 50 and 100.Flagyl 500-mg tablets are oblong, blue, film coated, with Flagyl debossed on one side and 500 on the other side; bottles of 50 and 100.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Metronidazole appears in cerebrospinal fluid, saliva, and breast milk in concentrations similar to those found in plasma. Reproduction studies ACTION AND CLINICAL PHARMACOLOGY . caution in patients with evidence of or history of Prescribing FLAGYL in the absence of a proven or strongly Read more about the prescription drug METRONIDAZOLE SUSTAINED-ACTION - ORAL. for Antimicrobial Susceptibility Testing of Anaerobic Bacteria; Approved To reduce the development of drug-resistant bacteria and maintain the effectiveness of FlagylMetronidazole has been shown to be carcinogenic in mice and rats (see Flagyl (metronidazole) tablets, 250 mg or 500 mg is an oral formulation of the synthetic nitroimidazole antimicrobial, 2-methyl-5-nitro-1H-imidazole-1-ethanol, which has the following structural formula:Flagyl (metronidazole) tablets contain 250 mg or 500 mg of metronidazole. metronidazole. These reports should aid the physician in selecting an antibacterial If no therapeutic alternatives to metronidazole are available, and concomitant administration with busulfan is medically needed, frequent monitoring of busulfan plasma concentration should be performed and the busulfan dose should be adjusted accordingly.The simultaneous administration of drugs that decrease microsomal liver enzyme activity, such as cimetidine, may prolong the half-life and decrease plasma clearance of metronidazole.The simultaneous administration of drugs that induce microsomal liver enzymes, such as phenytoin or phenobarbital, may accelerate the elimination of metronidazole, resulting in reduced plasma levels; impaired clearance of phenytoin has also been reported.Metronidazole may interfere with certain types of determinations of serum chemistry values, such as aspartate aminotransferase (AST, SGOT), alanine aminotransferase (ALT, SGPT), lactate dehydrogenase (LDH), triglycerides, and glucose hexokinase. Standards for Antimicrobial Susceptibility Testing; Twenty-fifth Informational In a mixed aerobic and anaerobic infection, antimicrobials appropriate for the treatment of the aerobic infection should be used in addition to Flagyl.INTRA-ABDOMINAL INFECTIONS, including peritonitis, intra-abdominal abscess, and liver abscess, caused by GYNECOLOGIC INFECTIONS, including endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection, caused by BONE AND JOINT INFECTIONS, (as adjunctive therapy), caused by CENTRAL NERVOUS SYSTEM (CNS) INFECTIONS, including meningitis and brain abscess, caused by LOWER RESPIRATORY TRACT INFECTIONS, including pneumonia, empyema, and lung abscess, caused by To reduce the development of drug-resistant bacteria and maintain the effectiveness of Flagyl and other antibacterial drugs, Flagyl should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

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