zoledronic acid bisphosphonate innopran xl

Follow your doctor's instructions very closely. The long duration of action of zoledronic acid is attributable to its high binding affinity for the active site of farnesyl pyrophosphate (FPP) synthase and its strong binding affinity to bone mineral.Zoledronic acid treatment rapidly reduced the rate of bone turnover from elevated post-menopausal levels with the nadir for resorption markers observed at 7 days, and for formation markers at 12 weeks. Zoledronic acid was administered once a year, until at least 211 patients in the study population had confirmed clinical fractures. Incidence of individual adverse reactions following the first infusion was: pyrexia (17.1%), myalgia (7.8%), influenza-like illness (6.7%), arthralgia (4.8%) and headache (5.1%). Zometa is used to treat high blood levels of calcium caused by cancer (also called You should not use Reclast and Zometa at the same time.Zoledronic acid may also be used for purposes not listed in this medication guide.You should not be treated with zoledronic acid if you are allergic to it.You should not be treated with zoledronic acid if are currently using any other bisphosphonate (such as any condition that makes it hard for your body to absorb nutrients from food (malabsorption);a dental problem (you may need a dental exam before you receive zoledronic acid);You may need to have a negative pregnancy test before starting this treatment.You should not breastfeed while using zoledronic acid.Zoledronic acid is given as an infusion into a vein. Bone biopsy results showed bone of normal quality with no evidence of impaired bone remodelling and no evidence of mineralisation defects. In a large clinical trial, local reactions at the infusion site, such as redness, swelling and/or pain, were reported (0.7%) following the administration of zoledronic acid. Teratogenicity was observed in rats at doses ≥ 0.2 mg/kg and was manifested by external, visceral and skeletal malformations. Brush and floss your teeth regularly. Your kidney function may also need to be checked.Pay special attention to your dental hygiene while using zoledronic acid. After 6 months, zoledronic acid showed 96% (169/176) and 89% (156/176) response and serum alkaline phosphatase (SAP) normalisation rates compared to 74% (127/171) and 58% (99/171) for risedronate (all p<0.001).In the pooled results, a similar decrease in pain severity and pain interference scores relative to baseline were observed over 6 months for zoledronic acid and risedronate.Patients who were classified as responders at the end of the 6 month core study were eligible to enter an extended follow-up period. Osteonecrosis of the external auditory canal has been reported with bisphosphonates, mainly in association with long-term therapy. - Poor oral hygiene, periodontal disease, poorly fitting dentures, history of dental disease, invasive dental procedures, e.g. The main molecular target of zoledronic acid in the osteoclast is the enzyme farnesyl pyrophosphate synthase. All patients should be encouraged to maintain good oral hygiene, undergo routine dental check-ups, and immediately report any oral symptoms such as dental mobility, pain or swelling, non-healing of sores or discharge during treatment with zoledronic acid. You may report side effects to FDA at 1-800-FDA-1088.Zoledronic acid can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, or pain or arthritis (including aspirin, Other drugs may affect zoledronic acid, including prescription and over-the-counter medicines, Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Copyright 1996-2018 Cerner Multum, Inc. The clinical relevance of these findings is unknown. 4.5 Interaction with other medicinal products and other forms of interaction6.6 Special precautions for disposal and other handling9. Zoledronic acid is only part of a complete program of treatment that may also include diet changes and taking calcium and vitamin supplements. Measurement of serum calcium before infusion of zoledronic acid is recommended for patients with Paget´s disease.Severe and occasionally incapacitating bone, joint and/or muscle pain have been infrequently reported in patients taking bisphosphonates, including zoledronic acid (see section 4.8).Osteonecrosis of the jaw has been reported in the post-marketing setting in patients receiving zoledronic acid for osteoporosis (see section 4.8).

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